2023年6月2日 · The CCTG CX.5-SHAPE trial enrolled 700 patients with low-risk squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the cervix and randomly assigned them to radical hysterectomy or simple hysterectomy plus pelvic lymph node dissection.

An international randomized phase III trial comparing radical hysterectomy and pelvic node dissection (RH) vs simple hysterectomy and pelvic node dissection (SH) in patients with low-risk early-stage cervical cancer (LRESCC): A Gynecologic Cancer Intergroup study led by the Canadian Cancer Trials Group (CCTG CX.5-SHAPE).

An international randomized phase III trial comparing radical hysterectomy and pelvic node dissection (RH) vs simple hysterectomy and pelvic node dissection (SH) in patients with low-risk early-stage cervical cancer (LRESCC). A Gynecologic Cancer Intergroup study led by the Canadian Cancer Trials Group (CCTG CX.5-SHAPE).

2023年6月2日 · Simple hysterectomy with pelvic lymph node dissection may be a safe treatment option for patients with early-stage, low-risk cervical cancer and may help improve quality of life, according to results from the large, international phase III SHAPE clinical trial.

2023年7月17日 · ‍肿瘤瞭望：SHAPE试验纳入700名低风险IA2或IB1期宫颈癌患者，按1:1随机分入根治性子宫切除术和单纯性子宫切除术两组。 结果显示，单纯子宫切除术的3年盆腔复发率数据非劣于根治性子宫切除术；单纯子宫切除术的手术并发症较少，生活质量和性健康指标更好。 根据这项研究发现，单纯子宫切除术现在能否作为低风险早期宫颈癌的新治疗标准？ 杨宏英教授： SHAPE试验为低风险早期宫颈癌患者提供了一种可行的手术方法，但单纯子宫切除术在低风 …

2023年6月8日 · SHAPE试验纳入700名低风险IA2或IB1期宫颈癌患者，患者按1:1随机分入根治性子宫切除术和单纯性子宫切除术两组。 两个手术组都包括盆腔淋巴结清扫和可选的前哨淋巴结（SN）定位。 试验方案. 患者按合作组、SN定位（是vs否）、分期（IA2 vs IB1）、组织学类型（鳞状vs腺癌/腺鳞癌）和肿瘤分级（1-2 vs 3 vs不可评估）进行分层。 主要终点为3年盆腔复发率。 患者基线特征. 研究结果. 在中位4.5年的随访中，接受单纯子宫切除术的患者的3年盆腔复 …

2023年6月25日 · Many patients with early-stage, low-risk cervical cancer may be spared the side effects associated with radical hysterectomy and undergo simple hysterectomy with pelvic lymph node dissection instead, according to results of the international phase III SHAPE study presented at the 2023 ASCO Annual Meeting. 1 SHAPE found that simple hysterectomy ...

2019年9月27日 · The SHAPE study (Radical Versus Simple Hysterectomy and Pelvic Node Dissection in Patients With Low-Risk Early Stage Cervical Cancer; ClinicalTrials.gov identifier: NCT01658930) is an ongoing, open-label noninferiority trial in which 700 women with small (≤ 2 cm) cervical cancers are being randomly assigned to simple versus radical ...

2023年8月4日 · Findings from the SHAPE trial confirm that carefully selected women with early-stage cervical cancer can undergo a simple hysterectomy instead of a radical procedure without increasing their risk of disease recurrence. The findings are likely to set a new global standard of care for patients with lo …

SHAPE Primary trial objective: To show that simple hysterectomy in low risk cervix cancer patients is safe and is associated with less morbidity than radical surgery To show that overall survival will not be significantly different between rad hyst and simple hyst