Cryo-EM Structure of the African Swine Fever Virus - Cell Press
African swine fever virus (ASFV) is a large DNA virus that causes a lethal swine hemorrhagic disease and is currently responsible for widespread outbreaks in domestic pigs. Liu et al. …
Cryo-EM Structure of the African Swine Fever Virus
2019年12月11日 · In the present study, we report the cryogenic electron microscopy (cryo-EM) reconstruction of the ASFV capsid structure at 4.6-Å, providing a glimpse of this infectious …
Structural basis of RNA polymerase complexes in African swine …
2025年1月8日 · In this study, we purified endogenous ASFV RNAP from infected cells with Twin-Strep-tagged vRPB2 and resolved the structure of ASFV RNAP, which included eight core …
The cryo-EM structure of African swine fever virus unravels a …
Here, we used single-particle cryo-EM to analyze the three-dimensional structure of the mature ASFV particle. Our results show that the ASFV virion, with a radial diameter of ∼2,080 Å, …
Cryo-EM Structure of the African Swine Fever Virus - PubMed
2019年12月11日 · African swine fever virus (ASFV) is a large double-stranded DNA virus with an icosahedral multilayered structure. ASFV causes a lethal swine hemorrhagic disease and is …
African swine fever virus (ASFV) is a large DNA virus that causes a lethal swine hemorrhagic disease and is currently responsible for widespread outbreaks in domestic pigs. Liu et al. …
Architecture of African swine fever virus and implications for viral ...
African swine fever virus (ASFV) is highly contagious and often lethal. With no vaccine or effective treatment, infections often require large-scale culling of pigs. Wang et al. apply cutting-edge …
A unified view on enzyme catalysis by cryo-EM study of a DNA
2024年2月28日 · In this work, we use cryo-EM to evaluate the current catalytic theories with Asfv Top2 and examine its induced fit conformational changes upon binding of ligands. The results …
Cryo-EM structure of DNA polymerase of African swine fever virus
2024年9月23日 · ASFV DNA polymerase (DNAPol) is responsible for genome replication and highly conserved in all viral genotypes showing an ideal target for drug development. Here, we …
全文编译！我国科学家发表Science论文解析非洲猪瘟病毒的高分辨率三维结构并揭示它的组装机制 …
2019年11月18日 · asfv组装始于病毒内膜前体的出现，该内膜前体可能来自内质网，然后通过衣壳层的逐步组装而形成二十面体中间体和二十面体颗粒。在病毒组装的 ...