AT1 receptor signaling pathways in the cardiovascular system
Accumulating evidence shows the complex picture of AT1 receptor-mediated signaling; AT1 receptor-mediated heterotrimeric G protein-dependent signaling, transactivation of growth …
The role of Agonistic Autoantibodies to the Angiotensin II Type …
AT1-AAs bind and activate g-coupled AT1 receptors to increase ANGII sensitivity and to stimulate downstream pathways to elevate circulating concentrations endothelin 1, sFlt-1, and ROS that …
AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody
Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, and hypertensive …
Prophylactic antithrombin III administration during pregnancy ...
1992年6月1日 · We have previously found a transient increase of TAT levels in congenital AT1Q deficiency patients with deep vein thrombosis after the administration of ATZ, and have …
AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) …
2018年3月19日 · Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, …
Advances in the allostery of angiotensin II type 1 receptor
2023年6月17日 · Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract …
Role and mechanism of AT1-AA in the pathogenesis of HELLP …
2018年1月10日 · Research in recent years has discovered that agonistic autoantibody against type-1 angiotensin II receptor (AT1-AA) can exert an agonist-like effect through activation of …
Angiotensin II type 1 receptor autoantibody (AT1-AA)-mediated …
AT1-AA are detectable in animal models of preeclampsia and are responsible for elevation of soluble fms-related tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng), oxidative stress, and …
Angiotensin II type 1-Receptor Autoantibody (AT1-AA) -mediated ...
In preeclampsia, agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AA) are described. They induce NADPH oxidase and the MAPK/ERK pathway leading to NF-κB and …
Abstract —Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, …