2022年7月1日 · In this review, we will demonstrate how ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy. The ATF/CREB family in mammals represents a large group of basic-region leucine zipper (bZIP) transcription factors (TFs) with many physiological functions.

2005年4月26日 · Here we demonstrate that systemic neutralization of TGF-β activity in mice restores expression of a distinct cytotoxic gene program in CD8+ T cells, which promotes antigen-specific tumor clearance in vivo. Current cancer therapies are designed to target the TGF-β signaling pathway primarily in the tumor.

In this study, we demonstrate that inhibition of HO-1 activity in murine bone marrow-derived immature DCs (iDCs) resulted in DCs with raised intracellular ROS levels, a mature phenotype, impaired phagocytic and endocytic function, and increased …

Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN- γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells.

In this review we focus on the transcriptional pathways that control tumor infiltrating CD8+ T cell (TIL) function. Simultaneous restraint of overlapping inhibitory pathways may confer TIL resistance to multiple mechanisms of suppression traditionally referred to as exhaustion, tolerance, or anergy.

2022年11月16日 · Naïve CD8 + T lymphocytes exposed to certain inflammatory cytokines undergo proliferation and display increased sensitivity to antigens. Such ‘cytokine priming’ can promote the activation of potentially autoreactive and antitumor CD8 + T cells by weak tissue antigens and tumor antigens.

2014年6月6日 · In this study, we demonstrate that inhibition of HO-1 activity in murine bone marrow-derived immature DCs (iDCs) resulted in DCs with raised intracellular ROS levels, a mature phenotype, impaired phagocytic and endocytic function, and increased capacity to stimulate antigen-specific CD8 T cells.

hyperphosphorylation of CREB/ATF1 transcription factors. Phosphorylation of CREB is known to be associated with up-regulation of CD86 and secretion of the cytokine, IL-10 cytotoxic T lymphocytes (CD8 þ T) Inhibited ATF1 inhibited the transcriptional of granzyme B and interferon g killing ability of cytotoxic T lymphocytes is reduced. Tumor cells

2017年9月11日 · CD8 + T cell contact with cognate antigen leads to intracellular T cell receptor (TCR)-mediated signaling that, along with co-stimulatory signals, orchestrates gene expression programs to control...

In this review, we will demonstrate how ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy. Keywords: Anti-tumor effect, ATF, bZIP, Cancer, Immunity, Tumorigenesis.