2017年9月13日 · Autophagy is mediated by dozens of autophagy-related (Atg) proteins, among which Atg4 is the sole protease that regulates autophagy through the processing and …

We discover that human ATG4s promote autophagosome formation independently of their protease activity and of ATG8 family processing. ATG4 proximity networks reveal a role for …

2021年5月6日 · The ATG4 family of proteases are thought to regulate autophagosome formation exclusively by processing the ubiquitin-like ATG8 family (LC3/GABARAPs). We discover that …

2021年5月7日 · The ATG4 proteases are key regulators of autophagy. Until recently it was thought that their main function was to mediate the processing of ATG8 family members. A …

自噬由数十种自噬相关 (Atg) 蛋白介导，其中 Atg4 是唯一通过 Atg8 的加工和解偶联来调节自噬的蛋白酶。 由于 Atg4 活性对于自噬至关重要且具有高度特异性，因此 Atg4 是开发自噬特异性 …

6 天之前 · 该研究发现Atg4-Atg8系统独立于ESCRT促进膜闭合，为理解膜闭合的基本规律提供了新的角度。 Atg4-Atg8体系、ESCRT在自噬中均发挥不止一种功能。 该研究通过动态观察分 …

2021年7月1日 · The ATG4 proteases are key regulators of autophagy. Until recently it was thought that their main function was to mediate the processing of ATG8 family members. A …

2021年2月15日 · The ATG4 protease is essential for autophagy as it controls ATG8 lipidation, a key step in autophagosome biogenesis. This review describes how ATG4 integra

2016年4月1日 · In this review, we described how Atg4 proteases are involved in autophagy process, their roles in cancer biology and recent progress in the development of Atg4 target …

As the Atg4 activity is essential and highly specific to autophagy, Atg4 is a prospective target for developing autophagy-specific inhibitors. In this review article, we summarize our current …