2024年12月24日 · ATG4B (Autophagy Related 4B Cysteine Peptidase) is a Protein Coding gene. Diseases associated with ATG4B include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7. Among its related pathways are Selective autophagy and Autophagy pathway.

atg4b被认为是atg4的主要异构体，因为它对所有底物具有最宽的谱，其次是atg4a，而atg4c和atg4d的活性最低。 LC3-I最终与PE分子结合形成膜结合型LC3-II。 LC3-II特异性地针对伸长的自噬体，在与溶酶体融合之前一直停留在自噬小体上。

2017年9月13日 · Autophagy is mediated by dozens of autophagy-related (Atg) proteins, among which Atg4 is the sole protease that regulates autophagy through the processing and deconjugating of Atg8. As the Atg4...

Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene. [4] Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging.

本研究揭示了ATG4家族蛋白的ATG4B，在维持固有免疫平衡中的调控作用。 在病毒感染后，ATG4B能够招募TBK1靶向自噬蛋白GABARAP，TBK1通过其LIR (Lc3--interacting region)motif与GABARAP的LDS (LIR docking site)结合，使得TBKI被GABARAP包裹进自噬小体，并输送至自噬溶酶体中降解。 此外，ATG4B的特异性小分子抑制剂S130，能够通过抑制ATG4B的活性解除ATG4B介导的TBK降解，从而增强TBK1，增强 抗病毒免疫反应，抑制病 …

2023年11月22日 · ATG4B（Autophagy-related 4B）重组蛋白是自噬调控中的一员，扮演着精密剪切和激活ATG8家族蛋白的角色。 本文将深入研究ATG4B重组蛋白的结构特征、功能，以及其在自噬过程和细胞生物学中的关键作用。

Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed.

2017年12月11日 · Inhibiting ATG4B in combination with radiotherapy in treating mice with intracranial GBM xenograft markedly slows tumor growth and provides a significant survival benefit. Our work describes an MST4-ATG4B signaling axis that influences GBM autophagy and malignancy, and whose therapeutic targeting enhances the anti-tumor effects of radiotherapy.

2021年10月27日 · By grafting Atg4B-cleavable peptide to AIE fluorophore, the peptide-based probe can carry out real-time visualization of Atg4B activity with guaranteeing high specificity, serving as a great breakthrough to the detection of autophagy process in various autophagic cells, animal tissues, and even human pathological tissues.

该文章以自噬关键蛋白ATG4B为靶点，通过计算机虚拟筛选和建立荧光共振能量转移的体外高通量筛选体系，筛选得到新型的ATG4B小分子抑制剂S130。 通过对自噬信号通路的研究，发现S130不影响自噬体功能及其与溶酶体的融合，而是抑制了LC3-PE的去脂化过程，最终阻断细胞自噬。 这为进一步明确ATG4B在自噬信号通路中的调控作用提供了新的理论基础。 通过抗肿瘤作用的研究，发现S130可有效抑制结肠癌细胞的生长，且营养缺乏能进一步增强S130的抗肿瘤效果，而 …