相对高浓度的Ca 2＋ 可以激活胞质中的钙蛋白酶，钙蛋白酶进一步切割ATG5形成ATG5－tN，ATG5－tN与线粒体膜上的抗凋亡蛋白BCL－XL结合，影响线粒体膜通透性和膜电位的改变，从而促进凋亡。

2012年10月12日 · In our study, we re-evaluated the role of autophagy in cell death and cell survival under stress conditions, especially starvation, using different Atg5 deficient cells, including two cell lines with inducible Atg5 deletion or expression.

Atg5是参与自噬泡中吞噬细胞膜延伸的关键蛋白，它与Atg12形成组成型的复合物。 在此过程中，首先Atg7作为类E1泛素活化酶激活Atg12；然后Atg12被传递给类E2泛素转移酶Atg10；最后Atg12与Atg5结合形成复合物。

2020年12月4日 · In this study, we investigated the effect of chloroquine (CQ) and its combination with cisplatin (CDDP) in drug-resistant EOC cells. We used the three EOC cell lines CDDP-resistant A2780-CP20,...

ATG5通过LC3将V1V0-ATPase (空泡质子泵)从MVBs中分离出来，从而减少MVBs管腔的酸化。 与相应细胞裂解产物中LC3-II与LC3-I的比值相比，新出现的外泌体强烈富集LC3II (相对于LC3-I)。

2023年6月5日 · Autophagy-related 5 (Atg5) knockout (KO) improves the growth of NIH 3T3 and Ras-NIH 3T3 cells. a Growth rates of NIH 3T3, Ras-NIH 3T, and their Atg5 KO cells were determined. Data was expressed as percentage growth relative to that of Day 1 of each cell line.

ATG12-ATG5和 LC3 是自噬体膜上两种标志性蛋白，可通过western blot检测标志性蛋白的水平来判断机体的自噬现象。 但由于ATG12-ATG5仅存在于自噬早期阶段的双层膜上；且LC3在自噬过程中不断被切割和降解，所以很难单纯据此判断机体自噬是否被激活或抑制。

2025年1月15日 · We identify lysophosphatidic acid and serine as glycolytic intermediates that trigger PC death and demonstrate that the deletion of GLUT2 in ATG5-deficient mice mitigates PC neurodegeneration and...

2012年3月9日 · Through this study, we have uncovered a previously unknown critical function of the Atg12-Atg5-TECPR1 complex in autophagosome maturation and propose that the interaction between TECPR1 and Atg12-Atg5 provides fusion specificity between autophagosomes and …

2006年9月24日 · Here, we report that Atg5, in addition to the promotion of autophagy, enhances susceptibility towards apoptotic stimuli. Enforced expression of Atg5-sensitized tumour cells to anticancer drug...