微管相关蛋白1轻链3 (MAP1LC3)，是Atg8在哺乳动物中的同源物。 LC3/Atg8 被具有蛋白内切酶活性的 Atg4 在羧基端剪切，生成胞浆型 LC3-I。

2025年3月3日 · In this study, using TurboID-based proximity labeling, we identify the retromer subcomplex comprising sorting nexin 1 (SNX1), SNX2a, and SNX2b as interacting partners of ATG8. Remarkably, SNX proteins decorate ATG8-labeled autophagosomes and facilitate their coordinated movement along microtubules.

2025年1月5日 · Intracellular recycling via autophagy is governed by post-translational modifications of the autophagy-related (ATG) proteins. One notable example is ATG4-dependent delipidation of ATG8, a...

Atg 基因通过 Atg12-Atg5 和 LC3-II （Atg8-II） 复合物控制自噬体的形成。 Atg12 以需要 Atg7 和 Atg10（分别为 E1 和 E2 样酶） 的泛素样反应与 Atg5 偶联。 然后，Atg12–Atg5 连接物与 Atg16 非共价反应形成更大的复合物。

为了深入探究植物自噬调控机制，本研究通过蛋白邻近标记技术深入分析了 ATG8 邻近互作蛋白组 ， 鉴定到了新的 A TG8 互作蛋白： SNX1 ， SNX2A 和 SNX2B ，它们属于 Retromer 复合体的组分。

2023年10月6日 · Here we show that Saccharomyces cerevisiae Atg8–PE and E1–E2–E3 enzymes together construct a stable, mobile membrane scaffold. The complete scaffold formation induces an in-bud in prolate-shaped...

2024年1月1日 · Interaction studies have identified that, apart from SGS3, the ARM of VISP1 also interacts with CMV 2b protein, preferably with its tetrameric form. The leaves coexpressing VISP1, ATG8, and 2b showed the formation of autophagosome granules upon treatment with E64d.

Autophagy involves de novo formation of double membrane-bound structures called autophagosomes, which engulf material to be degraded in lytic compartments. Atg8 is a ubiq-uitin-like protein required for this process in Saccharomyces cerevisiae that can be conju-gated to the lipid phosphatidylethanolamine by a ubiquitin-like system.

2024年5月20日 · Using an AI-assisted approach, we identified Rab3GAP-like (Rab3GAPL) as a key membrane trafficking node that controls plant autophagy negatively. Rab3GAPL suppresses autophagy by binding to ATG8, the core autophagy adaptor, and deactivating Rab8a, a small GTPase essential for autophagosome formation and defense-related secretion.

自噬核心具有两种结合途径，分别将自噬相关基因8（atg8）的产物与磷脂酰乙醇胺（pe）和atg5与atg12结合，从而有助于囊泡的延长和封闭。 大米有六个ATG8基因，到目前为止尚未在功能上得到确认。