ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene. [5][6] This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [6]

2016年8月1日 · IF1 bound to the H + -ATP synthase inhibits both the synthase and hydrolase activities. Phosphorylation of S39 of IF1 by mtPKA prevents its binding to the ATP synthase. IF1 is a post-transcriptionally regulated protein that triggers aerobic glycolysis. IF1 plays a prominent role in oncogenesis, stemness and mitohormesis.

2024年12月24日 · ATP5IF1 (ATP Synthase Inhibitory Factor Subunit 1) is a Protein Coding gene. Diseases associated with ATP5IF1 include Mitochondrial Disease and Fallopian Tube Adenocarcinoma. Among its related pathways are Electron transport chain: OXPHOS system in mitochondria and Glucose / Energy Metabolism. An important paralog of this gene is MTHFS.

2022年5月16日 · We found that inhibitory factor 1 of the mitochondrial FoF1-ATP synthase (ATPIF1), a protein known to inhibit ATP hydrolysis by the reverse function of ATP synthase during ischemia, was significantly upregulated in pathological cardiac hypertrophy induced by pressure overload, myocardial infarction, or α-adrenergic stimulation.

线粒体是真核细胞中动态双层膜结构的细胞器,由外至内可以划分为四个功能区,分别是线粒体外膜 (OMM),线粒体膜间隙,线粒体内膜 (IMM)和线粒体基质.在线粒体内膜上的复合体V (complex V)即为ATP合酶,其主要功能是合成ATP.实际上,ATP合酶既合成也水解ATP,对细胞ATP水平有 ...

This study aims to understand ATP synthase inhibitory factor 1's (ATPIF1's) role in peripheral nerve regeneration (PNR) using a murine model of sciatic nerve crush injury. Histological exams and behavior assessments revealed ATPIF1 absence hindered nerve tissue reconstruction, delaying sensory and functional recovery.

2021年1月9日 · Overexpression of ATPIF1 contributed to the maintenance of normal structure of mitochondria, inhibiting activation of mitophagy and other signaling proteins (e.g., KLF4 and Tie2). The expression of KLF4 returned to normal in CCM3-KO EPCs after 2 days of re-overexpression of CCM3, but not other signaling proteins.

2022年5月16日 · Using ATPIF1 gain- and loss-of-function cell models, we demonstrated that stalled electron flow due to impaired ATP synthase activity triggered mitochondrial ROS generation, which stabilized HIF1 α, leading to transcriptional activation of glycolysis.

ATP合酶的活性受抑制因子 (ATPIF1)的调节。 ATPIF1与ATP合酶结合后,对其ATP合成和水解功能进行抑制,从而影响线粒体和细胞内ATP水平。

2025年2月9日 · ATPase inhibitory factor 1 (ATPIF1/IF1) was identified as essential for PARK2 recruitment and mitophagy in cultured cells. The expression of human ATPase inhibitory factor 1 (hIF1) inhibits the activity of oxidative phosphorylation and mediates the shift of neurons to an enhanced aerobic glycolysis.