2024年12月24日 · ACVR2A (Activin A Receptor Type 2A) is a Protein Coding gene. Diseases associated with ACVR2A include 2Q23.1 Microduplication Syndrome and Fibrodysplasia Ossificans Progressiva. Among its related pathways are Signaling by TGFB family members and Signaling by NODAL.

2024年11月6日 · ACVR2A（激活素受体2A）和ACVR2B（激活素受体2B）是转化生长因子β（TGF-β）受体超家族中的两个重要成员，作为激活素A的II型受体，它们在细胞生长、分化和组织修复等多种生理过程中发挥关键作用。 这两种跨膜蛋白具有富含半胱氨酸的配体结合域和激酶活性催化结构域，通过与激活素等配体结合，激活下游信号通路如Smad2/3和MAPK，从而调节骨骼肌质量、脂肪代谢、胚胎发育等。 尽管两者在功能上有重叠，但在特定组织中的表达和对配 …

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors.

2023年9月13日 · Sotatercept 是一款潜在 “first-in-class”IIA 型激活素受体（ACVR2A）融合蛋白，可将 ACVR2A 经过改造的细胞外域与抗体的 Fc 端融合在一起，阻断激活素与细胞膜上的受体结合，从而降低激活素介导的信号传导。 研究表明，转化生长因子β（TGF-β）超家族成员介导的细胞增殖和抗凋亡信号通路失衡是驱动 PAH 患者肺血管重塑的重要机制之一。 激活素 2A 型受体（ACVR2A）便是 TGF-β 超家族的成员之一。 因此，靶向 ACVR2A 的药物是逆转肺血管重 …

ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A.

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed: 17911401).

2025年2月8日 · activin receptor type-2A, activin A receptor, type IIA. Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.

2017年8月18日 · Here, we generated mice with conditional deletion of activin receptor (ACVR) type 2A, ACVR2B, or both, in osteoblasts, to determine the contribution of activin receptor signaling in regulating bone mass. Immunohistochemistry localized ACVR2A and ACVR2B to osteoblasts and osteocytes.

Sotatercept 是一种潜在的“first-in-class”IIA型激活素受体（ACVR2A） 融合蛋白，可以将改造过的ACVR2A细胞外区域与抗体的Fc末端融合起来以阻挡 激活素 绑定细胞膜上的受体，从而降低了由激活素激发的信号传导。 研究已经证明 转化生长因子 β (TGF-β)超级家族成员介导的细胞增殖和抗凋亡 信号通路 的不平衡是推动PAH患者肺血管重塑的主要机制之一。 作为TGF-β超级家族的一员，ACVR2A型激活素受体因此成为靶点，该类药物可能是逆转肺血管重构的有效途径。 2021 …

BMPR2 is a type II Transforming Growth Factor (TGF)-β family receptor that is fundamentally associated with pulmonary arterial hypertension (PAH) in humans. BMPR2 shares functional similarities with the type II activin receptors ACVR2A and ACVR2B, as it interacts with an overlapping group of TGF-β family growth factors (GFs).