Axokine, a second-generation neurotrophic factor that is related to ciliary neurotrophic factor (CNTF), is under development by Regeneron for the potential treatment of obesity and associated complications such as type 2 diabetes.

而对于CNTF而言，尽管人源的CNTF—Axokine已经被用于治疗肌萎缩性侧束硬化(amyotrophic lateral sclerosis)的临床试验,但人们发现在治疗过程中体内会产生相应的抗体【4】，由于担心带来的副作用，所以这项临床试验也被叫停了。

A recombinant version of human CNTF (rhCNTF), trade name Axokine, is a modified version with a 15 amino acid truncation of the C-terminus and two amino acid substitutions. It is three to five times more potent than CNTF in in vitro and in vivo assays and …

2025年1月7日 · Axokine is a 4-aminoquinoline antimalarial with actions similar to those of chloroquine but is mainly used in the treatment of SLE and rheumatoid arthritis. It interferes with digestive vacuole function within susceptible malarial parasites by increasing pH and interrupting with lysosomal degradation of Hb thus impeding normal cell function of ...

2015年10月1日 · Axokine (Regeneron Pharmaceuticals, Inc., Tarrytown, NY) is a recombinant variant of human CNTF (rvhCNTF). In Axokine, the last carboxy 15 amino acids are truncated, cysteine at position 17 is replaced by alanine and, glutamine at position 63 is replaced by arginine to increase stability and potency [104] .

2014年10月22日 · 1999年，Regeneron启动了在研药物AXOKINE用于肥胖症的临床研究，然而不幸的是这款产品在6年后仍然再蹈覆辙止步于III期临床试验。 这一系列的“滑铁卢”不免令人失落，Regeneron成立10多年来在神经系统领域内的研发几乎全军覆没，此时仍不得不为上市第一款新 …

Methods: The CNTF analogue, Axokine, was infused into the lateral ventricle of high-fat-fed mice for 1 week. Food intake, energy expenditure, body mass, glucose metabolism, and neurogenesis in the arcuate nucleus (ARC) of the hypothalamus were assessed 3 weeks after cessation of Axokine treatment.

睫状神经营养因子 (CNTF)类似物，CNTF可以模仿瘦素在下丘脑的效应，也成为减肥药研究的重要靶点之一。 正在开发的这类药物如美国Regeneron公司的Axokine。 该药为CNTF经基因工程改造后制成，在瘦素抵抗的动物模型中，显示出快速降低体重的作用。 但一项关键性Ⅲ临床试验结果显示，有2/3的受试者对该药产生 耐药性。 睫状神经营养因子 (CNTF)类似物，CNTF可以模仿瘦素在下丘脑的效应，也成为减肥药研究的重要靶点之一。

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Axokine is indicated for the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.