2022年6月24日 · HLA-B27 and Ankylosing Spondylitis. There are hundreds of HLA genes, each identified by a different number. One gene, HLA-B27, is strongly associated with a big family of rheumatic diseases called spondyloarthropathies. It includes: Axial spondyloarthritis; Axial psoriatic arthritis; Reactive arthritis

2018年6月5日 · HLA-B27 is a genetic test. The majority of people who have a positive HLA-B27 are perfectly healthy. HOWEVER, having a positive HLA-B7 can put you at increased risk of developing what we call spondyloarthritis-associated diseases.

Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759) [1] is a class I surface molecule encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells.

2023年7月4日 · The human leukocyte antigens (HLA) are gene loci in the major histocompatibility complex class I of genes on chromosome 6, present on all nucleated cells. This activity reviews the varied presentations of HLA-B27 associated syndromes.

2018年11月13日 · The human leukocyte antigen B27 (HLA-B27) blood test is used to help diagnose autoimmune disorders. Learn more about what to expect during the test.

HLA-B27 is a MHC class I molecule consisting of an alpha chain encoded in the MHC region on chromosome 6 and a non-MHC encoded beta chain, β 2 microglobulin. 26 different alleles have been identified which code for 24 different proteins designated HLA-B*2701–B*2725 (B*2722 was deleted on the discovery that it had the same sequence as B*2706 ...

2024年12月9日 · Learn how the HLA-B27 gene impacts your risk for Ankylosing Spondylitis and arthritis. Understand your test results and what they mean for your health.

Ever since the early 1970s, scientists have discovered a relationship between a gene called HLA-B27 and a disease called ankylosing spondylitis. Although this gene can be found in many people, it greatly increases the chance of developing a group of inflammation-related joint conditions, also known as spondyloarthritis.

2021年7月1日 · HLA-B27 is a gene that encodes a protein called human leukocyte antigen B27, which is a protein found on the surface of cells. This protein is involved in immunity. HLA-B27 plays a major role in spondylitis and is one type of the HLA-B gene.

2025年3月10日 · The B27 test, also known as the HLA-B27 test, is a blood test used to detect the presence of a specific genetic marker, HLA-B27, in an individual's blood. This test is commonly used to help diagnose and manage certain autoimmune disorders, such as ankylosing spondylitis, reactive arthritis, and other spondyloarthropathies.