Effects of alpha-interferon on serum beta-2-microglobulin
Interferons (IFNs) have the ability to enhance the expression of class I and II histocompatibility antigens. Accordingly, IFNs cause a rise in formation and release of B2M. Currently, treatment …
《自然·免疫学》：刷新认知！IFN-γ信号竟然会抑制杀伤性T细胞抗 …
2022年11月18日 · 结果显示，抗原呈递相关基因（H2-T23、B2m、Tap1、Tap2、Tapbp和Erap1）在ISG中富集，这些基因同样在ICB治疗后清除的sgRNA中富集，这提示这些基因能 …
β2-microglobulin functions as an endogenous NMDAR ... - Cell Press
2023年3月2日 · Our findings identify B2M as an endogenous NMDAR antagonist and reveal a pathophysiological role for circulating B2M in NMDAR dysfunction in DS and related cognitive …
Opposing Functions of Interferon Coordinate Adaptive and …
Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through PDL1. How these opposing effects are integrated to impact immune checkpoint blockade …
b2m蛋白（β2微球蛋白）调控细胞因子作用机制 - 华美生物
2023年8月9日 · 例如，b2m与肿瘤坏死因子（tnf）结合，可以增强tnf的效应，促进炎症反应和免疫细胞活化。 此外，B2M还与干扰素-γ（IFN-γ）等细胞因子相互作用，调节其在免疫应答和免 …
Hypoimmunogenic derivatives of induced pluripotent stem cells …
2019年2月18日 · B2M −/− CIITA −/− hiPSCs resulted in an IFN-γ release reaching roughly one-third of the spot frequency of the highly NK cell susceptible K562 line, whereas B2M −/− CIITA …
Resistance to checkpoint blockade therapy through inactivation of ...
2017年10月26日 · In pretreatment tumor samples, defects in the IFN γ pathway 11 were identified as a mechanism of primary resistance to anti-CTLA4 therapy. Moreover, in post-treatment …
【Science】干扰素信号传导和抗原呈递的解偶联能够克服JAK1缺失 …
为了研究肿瘤固有IFN信号对肿瘤特异性T细胞抗肿瘤效果的直接影响，团队在B16小鼠黑色素瘤细胞中建立了IFN信号缺陷的模型(Jak1或Jak2缺失)，进行体外过继转移研究。
Beta2-microglobulin (B2M) in cancer immunotherapies: Biological ...
2021年10月1日 · Accumulating evidence has shown that alterations of B2M gene and B2M proteins contribute to poor reaction to cancer immunotherapies by dampening antigen …
Lysine vitcylation is a vitamin C-derived protein modification that ...
2025年2月28日 · Previous studies showed that IFN-γ stimulation results in parallel pSTAT1 homodimers formation and recruitment to gamma IFN activation sites (GAS DNA elements), ...