PD-L1 also known as B7-H1 was characterized at the Mayo Clinic in 1999 as an immune regulatory molecule. [8] At that time, it was concluded that B7-H1 helps tumor cells evade anti-tumor immunity. [9]

细胞程序性死亡-配体1（Programmed cell death ligand 1，PD-L1）也称为表面抗原分化簇274（cluster of differentiation 274，CD274）或 B7同源体（B7 homolog 1，B7-H1），是人类体内的一种蛋白质，由CD274基因编码。

PD-L1首次被发现是由华裔学者 陈列平 教授在1999年作为B7家族的第3个成员B7-H1。次年，Tasuku Honjo与哈佛医学院的Gordon Freeman证实B7-H1能够与PD-1结合，抑制T细胞增殖以及细胞因子分泌，负调控淋巴细胞的激活。

Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). Ligation of B7-H1 co-stimulated T-cell...

在细胞免疫反应中，T细胞的增殖和活化不仅需要 T细胞受体 TCR识别APC或肿瘤细胞表面MHC提呈的第一信号，还需要共刺激分子提供的第二信号，B7家族是目前发现的共刺激分子家族之一,通过CD28受体家族与B7配体家族相互作用，激活或抑制T细胞的活化与增殖。 B7家族，属于免疫球蛋白超家族。 目前已发现11种B7蛋白，即B7-1、B7-2、B7-H1、B7-DC、B7-H2、B7-H3、B7-H4、B7-H5、BTNL2、B7-H6和B7-H7。 B7家族与肿瘤进展关联密切，在肿瘤免疫、自身免 …

2002年6月24日 · B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on...

2016年3月2日 · PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy and has elicited durable antitumor responses and long-term remissions in a subset of patients with a broad spectrum of cancers. How to improve, widen, and predict the clinical response to anti-PD therapy is a central theme in the field of cancer immunology and immunotherapy.

PD-L1 and PD-1 (PD) pathway blockade is a highly promising therapy and has elicited durable anti-tumor responses and long-term remissions in a subset of patients with a broad spectrum of cancers. How to improve, widen, and predict the clinical response to anti-PD therapy is a central theme in the field of cancer immunology and immunotherapy.

The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated immune response. Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T-lymph …

B7-H1是B7家族的第三个成员，可共同刺激T细胞增殖和白介素10分泌。 B7家族成员B7-1和B7-2与CD28相互作用，并在抗原特异性体液和细胞介导的免疫反应的启动中构成必需的T细胞共刺激途径。 在这里，我们描述了B7家族的第三个成员，称为B7-H1，它不结合CD28，细胞毒性T淋巴细胞A4或ICOS（诱导型共刺激物）。 B7 H1的连接共同刺激T细胞对多克隆刺激和同种异体抗原的反应，并优先刺激白介素10的产生。 B7-H1共刺激的作用需要白细胞介素2，尽管量很小。 因 …