Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. [5]

β-分泌酶1，也称为 β位淀粉样前体蛋白裂解酶1 、 β位APP裂解酶1 （BACE1）、 膜相关天冬氨酸蛋白酶2 、 memapsin-2 、 天冬氨酰蛋白酶2 和 ASP2，是一种酶，在人类中由BACE1 基因 编码。 [5] BACE1的表达主要在 神经元 中观察到。 BACE1是一种 天冬氨酸蛋白酶，对周围神经细胞中 髓鞘 的形成很重要：在小鼠中，当发生髓鞘形成时，BACE1的表达在产后阶段很高。 [6] 跨膜蛋白 在其细胞外 蛋白质结构域 中含有两个活性位点 天冬氨酸 残基，可作为 二聚体 发挥作用，其 …

2021年4月15日 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ₄₂, which aggregates into bioactive conformational species and likely initiates toxicity in …

许多bace1抑制剂，β-淀粉样蛋白聚集抑制剂，使用单克隆抗体的aβ和aβ清除策略处于临床试验的各个阶段。 这篇综述提供了对BACE1在疾病发病机理中的作用的深入评估，并重点介绍了开发出的治疗方法，以寻找更有效但毒性较小的BACE1抑制剂，特别是强调天然支架 ...

β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has historically focused on its actions as the β‐secretase responsible for the production of β‐amyloid beta, observed in Alzheimer's disease.

2024年12月24日 · BACE1 (Beta-Secretase 1) is a Protein Coding gene. Diseases associated with BACE1 include Alzheimer's Disease and Myositis. Among its related pathways are Alzheimer's disease and miRNA effects and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include enzyme binding and endopeptidase activity.

2009年5月12日 · BACE1调控的多种细胞机制是已知的，包括通过其5'非翻译区，microRNA和非编码反义RNA进行转录后调控。 BACE1是降低Abeta疗法的主要靶标，但是迄今为止，高亲和力生物利用抑制剂的开发一直是一项重大挑战。

BACE1 is the β-secretase enzyme that cleaves the transmembrane APP and, together with γ-secretase, generates Aβ species that in AD form increasingly large and conformationally complex soluble regionally deposited brain aggregates (see Figure 1). BACE1 cleavage of APP represents the rate-limiting step for Aβ production. Figure 1.

BACE1 exhibits all the functional properties of beta-secretase, and as the key enzyme that initiates the formation of Abeta, BACE1 is an attractive drug target for AD. This review discusses the identification and initial characterization of BACE1 and BACE2, and summarizes recent studies of BACE1 knockout mice that have validated BACE1 as the ...

2024年8月15日 · 目的 β淀粉样蛋白前体蛋白裂解酶1 （β-site APP cleaving enzyme 1， BACE1） 是阿尔茨海默病 （Alzheimer’s disease， AD）中淀粉样斑块形成的限速酶，其表达水平与活性在AD发生发展中起到关键作用。 BACE1的相互作用蛋白可以通过直接结合、间接结合、参与各种细胞信号转导通路等方式，直接或间接在BACE1的转录、翻译、修饰、胞内运输等各个环节对BACE1进行调节，从而参与AD的发生与疾病的进程。 本研究拟筛选并验证BACE1的相互作 …