BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. [5] [6] BAP1 encodes an 80.4 kDa nuclear …

The BAP1 gene provides instructions for making a protein called ubiquitin carboxyl-terminal hydrolase BAP1 (shortened to BAP1). This protein functions as a deubiquitinase, which means …

Oct 13, 2016 · BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumor (BIMT; formerly called …

Dec 24, 2024 · BAP1 is a deubiquitylase thought to be a key regulator of many cancer-associated pathways. Germline alterations in BAP1 have been characterized as predisposing variants to …

BAP1 is functionally a tumor suppressor (Proc Natl Acad Sci USA 2014;111:285) BAP1 is a deubiquitinase that associates with multiprotein complexes that regulate key cellular pathways, …

brca1关联蛋白1（bap1）是一种泛素蛋白羧基末端水解酶，已被确立为肿瘤抑制因子，利用其去泛素化活性来调节许多生物过程，包括dna损伤修复，细胞周期控制，染色质修饰，程序性细胞 …

Nov 15, 2021 · BAP1 tumor predisposition syndrome, also known as BAP1-TPDS or COMMON syndrome, is an inherited genetic disorder that may increase the risk of certain types of …

In this review, we summarize the current state of knowledge regarding the biological functions of BAP1, potential use of BAP1 signature in therapeutics, and advances in the field of targeted …

BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of …

BAP1 tumor predisposition syndrome is caused by mutations in the BAP1 gene. The BAP1 protein acts as a tumor suppressor, which means it helps prevent cells from growing and …

Jan 18, 2021 · BAP1 belongs to the deubiquitinase superfamily of enzymes, which are responsible for the maturation and turnover of ubiquitin as well as the reversal of substrate …

BAP1 tumor predisposition syndrome is an inherited disorder that increases the risk of a variety of cancerous (malignant) and noncancerous (benign) tumors, most commonly certain types of …

Feb 14, 2013 · Recent findings indicate that germline BAP1 mutations cause a novel cancer syndrome that is characterized, at least in the affected families that have been studied so far, …

基质蛋白包括RbmA、RbmC、Bap1，它们的基因分布在两个vps基因簇之间 ，被认为是生物被膜的骨架，粘合生物被膜中的组成部分，包括介质表面、细菌菌体、VPS、eDNA等。

BAP1 exerts its function through highly regulated deubiquitination of its substrates. As such, BAP1 orchestrates chromatin-associated processes including gene expression, DNA replication, and …

Nov 1, 2020 · BAP1 is a multifaceted tumor suppressor gene that regulates a wide variety of processes that are implicated in cancer.

BAP1 alterations significantly impact mesothelioma prognosis and treatment. Patients with BAP1-deficient tumors often exhibit distinct clinical characteristics, including a more indolent disease …

Sep 30, 2022 · We characterize MBD5 and MBD6 as important regulators of the BAP1 complex and maintain its transcriptional landscape, shedding light on the therapeutic potential of …

肾细胞癌简称肾癌，是肾实质肿瘤中最常见的一种恶性肿瘤。据统计，近30 年全球肾癌的发病率以每年3% 的速度增长；我国每年新增肾癌患者达8 万，每年因肾癌死亡的人数超过2 万。在临 …

在该研究中，樊嘉院士团队建立了以蛋白质组为核心肝内胆管癌患者的分子分型：炎症型(s1)、间质型(s2）、代谢型(s3）和分化型(s4)，这四个亚型在基因组、免疫微环境、治疗策略、临床 …