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越来越多的证据表明，内皮细胞功能障碍在cSVD病理生理学中扮演关键角色， 导致血脑屏障（BBB）的通透性增加。 这种亚急性的维持稳态失败可能导致基底膜的损伤和增厚，伴随血管壁硬度的增加。

2021年6月26日 · INVESTIGATE-SVDs will assess the relationships of BBB integrity, CVR, pulsatility and CSF flow in sporadic SVD and CADASIL using a multisite, multimodal MRI protocol. We aim to establish associations between these measures of vascular function, risk factors particularly BP and its variability, and b …

Materials and methods: We measured cerebral blood flow (CBF), cerebrovascular reactivity (CVR), and blood-brain-barrier (BBB) leakage in a group of 33 elderly subjects (age: 72.3 +/- 6.8 years, 17 males, 16 females). Leukoaraiosis brain regions were identified in each subject using fluid-attenuated inversion-recovery (FLAIR) MRI.

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BBB VVS- & ENTREPRENØRFIRMA ApS er vvs og blikkenslager og har deres daglige gang i København V og omegn. De blev etableret tilbage i 2014 som et anpartsselskab.

BBB已发展成为横跨北美（美国 和 加拿大）的国际性的一个非盈利组织，BBB从一开始就承诺无需政府扶持，所有经费靠收取诚信企业申请和管理费维持。