2023年10月4日 · Intravesical administration of Bacillus Calmette-Guérin (BCG) was one of the first FDA-approved immunotherapies and remains a standard treatment for bladder cancer....

2020年1月1日 · Here we show that intravenous administration of BCG profoundly alters the protective outcome of Mtb challenge in non-human primates (Macaca mulatta).

2023年10月9日 · Intravenous BCG confers protection against Mtb infection in rhesus macaques; we hypothesized that it might prevent tuberculosis in simian immunodeficiency virus (SIV) …

2025年1月1日 · High-dose intravenous BCG induces a robust increase in T cells and recruited macrophages into the airways. Notably, high-dose intravenous BCG also drives a prolonged …

We vaccinated wild-type (WT; C57BL/6J) mice intravenously (iv) or subcutaneously (sc) with BCG-TICE strain, the clinical vaccine strain used in North America. After BCG-iv vaccination, …

2022年6月8日 · Here, we investigated whether BCG-induced trained immunity protected against SARS-CoV-2 in the K18-hACE2 mouse model. Our data demonstrate that i.v. BCG (BCG-i.v.) …

2024年12月2日 · Animals that received IV BCG vaccination showed a significant increase in PPD-specific IgG avidity following vaccination, while those that received ID BCG vaccination did …

2023年7月16日 · Intradermal (ID) Bacillus Calmette-Guérin (BCG) is the most widely administered vaccine in the world. However, ID-BCG fails to achieve the level of protection needed in adults …

2024年11月16日 · 卡介苗静脉免疫（BCG-IV）能显著降低小鼠流感病毒（IAV）感染后的发病率和死亡率，而皮下注射卡介苗（BCG-SC）和对照组（PBS-IV）无保护效果。 BCG-IV在感染后 …

2023年10月4日 · Here, we examine IV BCG in several preclinical lung tumor models. Our findings demonstrate that BCG inoculation reduced tumor growth and prolonged mouse survival in …