B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene. [5][6][7] The BCL11A gene encodes for a regulatory C2H2 type zinc-finger protein, that can …

2024年12月24日 · BCL11A (BCL11 Transcription Factor A) is a Protein Coding gene. Diseases associated with BCL11A include Intellectual Developmental Disorder With Persistence Of …

2020年12月5日 · BCL11A is a transcription factor that represses γ-globin expression and fetal hemoglobin in erythroid cells. We performed electroporation of CD34+ hematopoietic stem …

2019年11月29日 · BCL11A functions mainly as a transcriptional repressor that is crucial in brain, hematopoietic system development, as well as fetal-to-adult hemoglobin switching. The …

Transcription factor B-cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger protein that is predominantly expressed in brain and hematopoietic tissue. BCL11A functions mainly …

Our findings reveal that direct γ-globin gene promoter repression by BCL11A underlies hemoglobin switching. During human development, the major hemoglobin expressed in red …

Here, we provide a brief overview of the fetal-to-adult hemoglobin switch that occurs in humans shortly after birth and review our current understanding of one of the most potent known …