2016年10月4日 · Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the pathogenesis of Alzheimer’s disease (AD), which is characterized with...

2022年1月28日 · Brain-derived neurotrophic factors (BDNFs) play an important role in maintaining synaptic plasticity in learning and memory. Considering AD as a synaptic disorder, BDNF has attracted increasing attention as a potential diagnostic biomarker …

该基因疗法将评估 脑源性神经营养因子 （bdnf）的aav基因疗法“aav2-bdnf”，作为ad潜在疗法的可行性。bdnf在人类大脑的内嗅皮层中产生，与记忆形成有关，但阿尔兹海默症患者中这一蛋白的含量低于正常水平。 bdnf是一种大蛋白，因此不易穿过血脑屏障。

针对bdnf的ad治疗策略主要包括增加内源性bdnf及其受体trkb的表达、靶向bdnf治疗和非特异性治疗。 经典抗AD药物，胆碱酯酶抑制剂多奈哌齐、加兰他敏可增加CREB和Akt磷酸化，活化受到AD抑制的下游通路Akt/CREB/BDNF-TrkB，增加BDNF及其受体的表达 [21] 。

Therefore, this review aims to summarize the latest progress in the field of BDNF and its biological roles in AD pathogenesis. We will discuss the interaction between BDNF and amyloid beta (Aβ) peptide, the effect of BDNF on synaptic repair in AD, and the association between BDNF polymorphism and AD risk.

2019年7月3日 · 研究结果表明，brad-r13及其活性代谢产物可以模拟bdnf的生理作用，并改善ad模型小鼠的突触功能障碍和认知缺陷。 长期口服给予BrAD-R13将以剂量依赖性方式在5XFAD小鼠中发挥治疗作用，BrAD-R13有望成为一种能够延缓疾病进程和保护神经的新型AD药物。

bdnf 的水平测定，发现生前认知能力的衰退速度与脑内 BDNF 表达水平负相关，而且进一步分析表明，AD 病理学与认 知衰退率的关系因BDNF 表达而异。

2007年8月1日 · Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic plasticity and structural integrity in the adult brain.

It was recently reported that brain-derived neurotrophic factor (BDNF) fluctuated according to AD severity, suggesting that BDNF might have utility for diagnostics and monitoring of therapeutic efficacy. The current study sought to examine whether BDNF levels varied according to AD severity, as previously reported.

大量的证据表明突触可塑性障碍是阿尔茨海默氏病(ad)的发病因素之一,而脑源性神经营养因子(bdnf)能够有效调控突触可塑性,改善认知功能,其与ad的关系已经得到广泛重视.本文就bdnf与ad的病因机制及其在治疗ad的药物学中的作用作一综述.