Brain-derived neurotrophic factor (BDNF) has emerged as a regulator of stable, late phase long-term potentiation (L-LTP) at excitatory glutamatergic synapses in the adult brain. However, the mechanisms by which BDNF triggers L-LTP are controversial.

One of the downstream genes induced by the L-LTP-inducing tetanus is BDNF. BDNF is a small dimeric protein that works through high affinity binding with the receptor tyrosine kinase, tropomyosin-related kinase B (TrkB). BDNF and TrkB are widely distributed across subregions of the hippocampus and the adult forebrain (Bramham and Messaoudi, 2005).

The role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin acts at pre- and post-synaptic levels. Recent studies have shown that BDNF regulates the transport of mRNAs along dendrites and their translation at the synapse, by modulating the initiation and elongation phases of protein synthesis, and by acting on specific ...

In addition, studies also show that BDNF is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions. The effects of BDNF on LTP are mediated by the TrkB receptor.

The effects of brain-derived neurotrophic factor (BDNF) in long-term synaptic potentiation (LTP) are thought to underlie learning and memory formation and are partly mediated by local protein synthesis. Here, we investigated the mechanisms that mediate BDNF-induced alterations in the synaptic proteome that are coupled to synaptic strengthening.

2016年2月18日 · Acute BDNF infusion induced long-term potentiation (LTP) of medial perforant path-evoked synaptic transmission and, concomitantly, enhanced hippocampal neurogenesis bilaterally, reflected by...

2014年1月1日 · Local protein synthesis induced by BDNF contributes to long-term synaptic plasticity and memory formation. Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory.

2014年1月1日 · With a focus on how BDNF signaling controls L-LTP, we distill and discuss the latest advances along three main lines: 1) tropomyosin-like kinase B (TrkB) receptor-coupled translational control underlying local protein synthesis and L-LTP, 2) mechanisms for BDNF-induced rescue of L-LTP when protein synthesis is blocked, and 3) BDNF-TrkB ...

2021年10月20日 · 而神经元来源的 bdnf 对 e-ltp 和 l-ltp 都很重要。 进一步的机制研究表明，两类细胞释放 BDNF 的动力学差异可能是导致不同形式 LTP 的原因。 并且，不同细胞来源的 BDNF 在记忆中也发挥着不同的作用。

2021年12月27日 · In this review, we examine the importance of spatial and temporal factors on BDNF activity, particularly in processes such as synaptogenesis, Hebbian plasticity, homeostatic plasticity, and the treatment of psychiatric disorders.