Recruitment of LC3 to damaged Golgi apparatus | Cell Death ...
2018年10月22日 · LC3 is a protein that can associate with autophagosomes, autolysosomes, and phagosomes. Here, we show that LC3 can also redistribute toward the damaged Golgi …
Autophagy induction via STING trafficking is a primordial function …
2019年3月6日 · To study DNA-induced autophagy, we transfected interferon-stimulatory DNA (ISD) into BJ cells, which are immortalized human fibroblasts. DNA transfection not only …
布雷菲德菌素A对HepG2细胞自噬的诱导作用 - 百度学术
为探讨新型抗癌药物布雷菲德菌素A(BFA)诱导肝癌细胞发生自噬性死亡的作用机制,以HepG2细胞作为研究对象,将细胞分成阴性对照组,不同浓度BFA组和阳性对照组(雷帕霉素),采用MTT法测 …
Brefeldin A delivery nanomicelles in hepatocellular carcinoma …
2021年10月1日 · In this study, we designed a novel polymeric nanomicelle based on the pluronic and polyethylene glycol 1000 vitamin E succinate (TPGS) to deliver BFA. TPGS is a water …
布雷菲德菌素A对HepG2细胞自噬的诱导作用 - RCEES
结果表明，BFA可引起HepG2细胞内自噬特征蛋白LC3-Ⅱ、Atg5、Beclin-1的蛋白表达水平明显增加；同时引起HepG2细胞活性降低、细胞数量减少、细胞核固缩和变形。
Brefeldin A induced inhibition of de novo globo- and neolacto …
1992年12月15日 · In order to account for BFA-induced accumulation of Lc3, the effect BFA of a as direct inhibitor of pl+ 4galactosyltransferase activity was tested using a crude cell …
Golgi-associated LC3 lipidation requires V-ATPase in ... - Nature
2016年8月11日 · AMDE-1-induced LC3 lipidation was colocalized with the Golgi complex, and was inhibited by the disturbance of Golgi complex. The integrity of the Golgi complex was also …
Regulation of autophagic flux by MSNs-BFA. (a) LC3
The LC3 level of cells treated with MSNs-BFA is even higher than that of cells treated with BFA alone, which is attributed to accumulation of autolysosomes by BFA induction and the...
NF-κB通路与内质网应激诱导的宫颈癌细胞自噬和细胞凋亡相关 …
2017年1月1日 · BFA增加了TC-1和HeLa细胞中LC3的点状染色以及通过TEM观察到的自噬体的数量。还评估了自噬通量。阻滞溶酶体中LC3降解的Bafilomycin导致LC3I和LC3II积累。BFA通 …
Brefeldin A inhibits colorectal cancer growth by triggering …
2019年1月22日 · We found that BFA treatment increased the interaction of Beclin 1 with ATG14L and decreased the binding of Beclin 1 with Bcl-2 (Fig. 2C). Moreover, either treatment with 3 …