Sprouty1 and Sprouty2 provide a control mechanism for the …
2002年10月28日 · Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular mechanism underlying this function has not been defined. Here we show that after stimulation by growth...
Identification of a New Sprouty Protein Responsible for the …
2014年6月10日 · We cloned and identified a new B. mori gene with a Spry domain similar to the Spry proteins of other organisms, such as fruitfly, mouse, human, chicken, Xenopus and zebrafish, and named it BmSpry. The gene expression analysis showed that BmSpry was transcribed in all of the examined tissues and in all developmental stages from embryo to adult.
Sprouty1和Sprouty2提供了Ras / MAPK信号通路的控制 ... - X-MOL
非磷酸化的Spry突变体不能结合Grb2并充当显性负离子，从而诱导ERK响应FGF延长活化，并促进FGF诱导PC12细胞中神经突的生长。 我们的发现表明Spry在负反馈机制中起作用，在该机制中，其抑制剂活性受翻译后机制快速可逆地控制。
Science | 摆脱PAM困扰—Cas9强势升级获得基因编辑新利器SpRY
总体而言，本研究开发的SpCas9突变体SpRY是当前对PAM序列兼容性最高的SpCas9突变体，几乎完全摆脱了PAM序列的限制，其在基因组范围内的编辑能力得到了极大的提高，而衍生而来的单碱基编辑系统让精准编辑几乎拓展至全基因组范围。
SPRY1 promotes cell proliferation and inhibits apoptosis by …
2021年12月27日 · SPRY1 could facilitate cell proliferation and cell cycle progression, and suppress cell apoptosis via activating the Hedgehog pathway in AML.
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and ...
2012年6月7日 · First, among 4 Spry genes, Spry1 is selectively highly expressed in developing primary bone marrow (pro)erythroblasts. Second, via a conditional loss-of-function approach, Spry1 is indicated to be functionally important in regulating balanced levels of erythroid progenitors versus differentiating erythroblast progeny, especially during anemia.
Sprouty1 is a broad mediator of cellular senescence
2024年4月26日 · Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinase (RTK) signaling conserved from flies to humans [1]. In mice, Spry genes mainly antagonize signaling by...
Inhibition of cardiomyocyte Sprouty1 protects from cardiac …
2019年1月11日 · Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia–reperfusion (I/R) injury.
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Spry1 Rabbit mAb - Selleck中国
建议使用 RIPA/NP-40 Lysis Buffer 制备裂解物。 湿转参考条件： 200 mA, 60 min。 1. 组织样品：破碎组织，加入适量冰冷的 RIPA/NP-40 Lysis Buffer （含PMSF），低温匀浆。 2. 贴壁细胞样品：吸去培养基, 用冰冷的 PBS 清洗细胞 2 遍。 加入适量冰冷的 RIPA/NP-40 Lysis Buffer （含PMSF），冰上静置裂解 5 min。 3. 悬浮细胞样品：将培养基转移至离心管中离心，弃上清，用冰冷的 PBS 清洗细胞 2 遍。 加入适量冰冷的 RIPA/NP-40 Lysis Buffer （含PMSF），冰上静 …