2008年12月1日 · We describe a test for the phagocytic efficiency of BMMs by exposing them to fluorescently labeled yeast zymosan bioparticles. Also, a method to deliver DNA or small interfering RNAs (siRNAs) into these hard-to-transfect cells is described.

骨髓源性巨噬细胞 （英語： Bone marrow-derived macrophage， BMDM）是指由科研实验室哺乳动物 骨髓 细胞生成的 巨噬细胞。 骨髓细胞中存在未分化的巨噬细胞前体，可以通过加入 巨噬细胞集落刺激因子 （macrophage colony-stimulating factor，M-CSF；CSF1）来分化培养 [1]，M-CSF是一个 细胞因子,诱导 细胞分化。 BMDM细胞常用于 免疫学 和 细胞生物学 研究 [2]。 ^ Weischenfeldt, Joachim; Porse, Bo. Bone Marrow-Derived Macrophages (BMM): Isolation and …

BMDM are primary cells and have the biological function and properties of macrophages differentiated from monocytes because there are mature, in contrast to macrophage cell lines, which are immature.

Bone-marrow-derived macrophage (BMDM) refers to macrophage cells that are generated in a research laboratory from mammalian bone marrow cells. [1][2][3] BMDMs can differentiate into mature macrophages in the presence of growth factors and other signaling molecules. [1][2] Undifferentiated bone marrow cells are cultured in the presence of ...

2024年9月12日 · Here we found that physiologically aged bone marrow monocytes/macrophages (BMMs) propagate senescence to multiple tissues, through extracellular vesicles (EVs), and drive age-associated dysfunction...

Bone marrow-derived macrophages (BMM) comprise a population of quiescent cells which can be activated by defined signals. Here, we directly compare the release of chemokines and monokines by BMM raised either in serum-supplemented or in serum-free medium in response to Listeria monocytogenes EGD or Mycobacterium bovis BCG infection.

2023年9月21日 · In this review, we delineate the metabolic and immune checkpoint characteristics of the AML BMM, with a focus on the roles of BMM cells e.g. tumor-associated macrophages, natural killer cells, dendritic cells, metabolic profiles and …

1 天前 · Designing Next-Generation Immune Cell Therapies with Nanoparticles. (a) Manufacturing workflow of the current ICT targeting solid tumors. (b–d) Nanoparticle-mediated approaches to overcome the issues of (b) tumor accessibility, (c) lengthy in …

Bone-marrow-derived macrophages in mammals are ubiquitously dispersed, mononucleated cells that have the capacity to fuse with each other to form specialized, multinucleated osteoclasts or giant cells. From: International Review of Cell and Molecular Biology, 2011

2021年3月19日 · This protocol describes the collection of bone marrow cells from the femur and tibia of mice, differentiation into bone marrow-derived macrophages (BMDM cells), and sampling from cultures. This protocol focuses on the efficient preparation of BMDM cells, providing a way to assess the function of macrophages.