2008年11月11日 · Here we review the different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and...

2022年3月15日 · Along with previous results, studies attempted to discover the underlying mechanisms of cross-talk between Notch and BMP for inhibiting neuronal fate and encouraging astrocyte differentiation. As shown in Figure 4, BMP2 can enhance Notch-induced transcriptional activation of Hes-5 in mouse neuroepithelial cells.

2021年5月27日 · In this study we showed BMP signaling was activated after ventricle ablation and acted epistatic downstream of Notch signaling. Inhibition of both signaling pathways differentially influenced ventricle regeneration and cardiomyocyte proliferation, as revealed by time-lapse analysis using a cardiomyocyte-specific FUCCI (fluorescent ...

2016年11月11日 · Notch sets responsiveness by regulating the cell-intrinsic BMP inhibitor, SMAD6 and SMAD6 affects BMP responses upstream of target gene expression, revealing a new paradigm for...

We linked BMP and Notch signalling pathway activity and function in human colonic epithelial cells, and normal and neoplastic tissue. BMP induced Notch through a γ-secretase-independent interaction, regulated by the SMAD proteins.

2008年7月1日 · BMPs are important local factors that regulate Runx2, which is an essential transcription factor for osteoblast differentiation. The Notch signaling pathway is involved in a variety of cellular function, including cell proliferation, differentiation and apoptosis. Notch signaling has a dual effect on osteoblast differentiation.

Notch信号是胚胎发育过程中高度保守的信号通路，Notch信号通过调节胚胎干细胞的分化，增殖与凋亡过程，调控哺乳动物的体节发生 。在哺乳动物中，Notch的配体有Jagged1, 2和DLL1，3，4，受体有Notch1-4。

2003年10月1日 · In this paper, we show that BMP2 enhances Notch-induced transcriptional activation of Hes-5 and Hesr-1 in mouse neuroepithelial cells. BMP2 stimulation, in addition to the introduction of the intracellular domain of Notch (NIC), resulted in enhanced activation of the Hes-5 gene promoter.

2004年2月2日 · Here we report that expression of the Notch target gene, Herp2, is synergistically induced upon activation of Notch and BMP receptor signaling pathways in endothelial cells. The synergy is mediated via RBP-Jκ/CBF-1 and GC-rich palindromic sites in the Herp2 promoter, as well as via interactions between the Notch intracellular domain and Smad ...

Notable paracrine signaling pathways include bone morphogenetic protein (BMP), Wnt, and Notch. An increased mechanistic knowledge of the significance of these pathways in MSC osteoblastogenesis is essential to develop methods to control cell fate in model systems and the eventual translation of that knowledge into novel therapeutics.