Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene. [4] [5] [6] The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.

bmp6、bmp15基因敲除雌性小鼠生育能力低，排卵率和受精率降低。bmp8通常与雄性生殖系统发育有关，包括精子发生和受精附睾发育。生殖细胞和精子发生的维持以及pgcs的形成依赖于bmp8。 bmpr-2是维持妊娠和着床后子宫功能所必需的。

骨形态发生蛋白 (bone morphogenetic protein，BMP)又称骨形成蛋白，是一组具有类似结构的高度保守的功能蛋白，属于TGF-β家族。 BMP能刺激DNA的合成和细胞的复制，从而促进间充质细胞定向分化为成骨细胞。 BMP是控制牙齿发育的重要分子。

2024年12月24日 · BMP6 (Bone Morphogenetic Protein 6) is a Protein Coding gene. Diseases associated with BMP6 include Iron Overload and Hemochromatosis, Type 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and …

2024年9月29日 · 骨形成蛋白6（BMP6）是TGF-β（转化生长因子β）超家族中的一种重要生长因子，对骨骼形成、细胞分化和组织修复等生物学过程具有关键作用。 骨形成蛋白6 (BMP6)是一种蛋白质，是由BMP6基因编码的。 该基因编码的是TGF-beta（转化生长因子-beta）超家族蛋白的分泌配体，这个家族的配体与各种TGF-beta受体结合，导致SMAD家族转录因子的招募和激活，从而调节基因表达。 BMP6能够诱导间质干细胞的所有成骨标志物。 该蛋白调控广泛的生物过 …

Bone morphogenetic protein 6 (BMP6) belongs to transforming growth factor β(TGF-β) superfamily. The fate determinations of stem cells require complex regulatory networks that involve BMP6 signaling pathway. Recent studies have demonstrated that BMP6 plays crucial roles in controlling the self-renewal and differentiation of stem cells.

2025年1月15日 · BMP6 emerges as a promising biomarker for DCM, and its functional role in exerting an antifibrotic effect underscores its potential as a therapeutic target.

2025年1月4日 · BMP6 plays a critical role in breast cancer cell aberrant proliferation and chemoresistance and may serve as a novel diagnostic biomarker or therapeutic target for breast cancer. BMP4 and BMP6, from two different BMP subclasses, and their antagonists noggin and sclerostin were variably expressed in melanocytes and keratinocytes in human skin

2025年1月15日 · Bulk RNA-seq, single-cell RNA-seq, Mendelian randomization analysis, animal model construction, and BMP6 knockdown were utilized to identify and validate potential specific markers and targets for intervention in DCM heart failure. We found that DCM hearts exhibit pronounced inflammatory cell infiltration and fibrosis.

2023年12月1日 · BMP6（Bone Morphogenetic Protein 6）是TGF-β超家族中的一种生长因子，对于骨骼形成、细胞分化和组织修复等生物学过程具有重要作用。 本文将介绍BMP6重组蛋白的结构、功能，以及其在医学研究和临床应用中的潜在前景。