bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC 50 s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro ...

BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC 50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.

2021年1月18日 · Phosphatase and Tensin Homolog on chromosome 10 (PTEN) antagonizes PI3K activity by dephosphorylating PIP3, thus suppressing PI3K/AKT signaling that could prevent IR induced cytotoxicity. The...

2015年1月1日 · Here we investigate the inhibition of PTEN by four available PTEN inhibitors, bpV (phen), bpV (pic), VO-OHpic and SF1670 and compared this inhibition with that of only 3 other related enzymes, the tyrosine phosphatase SHP1 and the phosphoinositide phosphatases INPP4A and INPP4B.

2024年7月29日 · Bisperoxovanadium (bpV), a derivative of vanadate, is a putative inhibitor of PTEN. Mxene-bpV, through PTEN inhibition and Akt activation, was more effective than bpV(HOpic) alone in reducing cerebral infarct sizes and promoting brain function recovery after MCAO/R injury in mice. Comparable results were obtained in the in vitro experiments.

bpV(phen) trihydrate，一种胰岛素模拟物，是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂，对 PTEN，PTP-β 和 PTP-1B 的 IC50 为 38 nM，343 nM 和 920 nM。 bpV(phen) trihydrate 在体外抑制原生动物寄生虫利什曼原虫的增殖。

2024年7月3日 · ASME BPV IV-2019是美国机械工程师学会（American Society of Mechanical Engineers，简称ASME）颁布的锅炉及压力容器规范第四部分的2019年版，它是关于加热锅炉建造的国际性规范。该规范详细规定了加热锅炉建造的...

2025年1月15日 · We first assessed the dose–response inhibition of PTEN by three standard bisperoxovanadium (bpV) complexes, namely bpV(phen), bpV(HOpic) and bpV(bipy) (Fig. 1A). We conducted in vitro phosphatase activity assays using bacterially expressed GST-PTEN and water soluble substrate (C8:0-PI(3,4,5)P 3).

2025年1月15日 · Our study highlights the complexity of PTEN inhibition by first-generation compounds and their limitations, such as low specificity, adverse effects and non-specific mechanisms of action, and emphasizes the need for developing more selective and potent PTEN inhibitors with improved efficacy and well-defined mechanisms of actions. 1. Introduction.

在具有肾缺血/再灌注损伤的小鼠模型中，通过bpV(HOpic)抑制PTEN可加速其肾功能不全以及促进肾小管损伤。PTEN的抑制可加强肾小管细胞的凋亡，这一过程与caspase-3的过度激活相关。