Dec 24, 2024 · BRD1 (Bromodomain Containing 1) is a Protein Coding gene. Diseases associated with BRD1 include Nodular Prostate and Spinocerebellar Ataxia, X-Linked 5 . Among its related pathways are Gene expression (Transcription) and Chromatin organization .

Feb 17, 2025 · In our investigation, we have uncovered a novel role for BRD1 as an oncogene implicated the regulation of lipid metabolism in HCC progression. Specifically, the deficiency of BRD1 impedes the...

Jun 7, 2021 · Here, we show that the Arabidopsis thaliana bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and critical for SWI/SNF genomic targeting. These three BRDs interact directly with multiple SWI/SNF subunits, including the BRAHMA (BRM) catalytic subunit.

Jul 24, 2018 · Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic potential of BRD1 inhibition in...

Feb 19, 2025 · 为了进一步探究 brd1 在 hcc 发展中的潜在致癌作用，研究人员利用两种 brd1 特异性短发夹 rna（shbrd1#1 和 shbrd1#2）构建了 brd1 下调的细胞系。 通过 Edu 染色和集落形成实验，他们发现 BRD1 下调的 HCC 细胞增殖能力明显下降。

该基因编码一种含溴结构域的蛋白质，该蛋白质定位于细胞核并可与 DNA 和组蛋白尾部相互作用。 编码的蛋白质是 MOZ/MORF 乙酰转移酶复合物的组成部分，可以刺激组蛋白 H3 和 H4 的乙酰化，从而可能在基因激活中发挥作用。 在某些研究人群中，该基因的变异与精神分裂症和双相情感障碍有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2017 年 3 月] This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and …

Feb 9, 2025 · Reduced BRD1 expression is associated with Schizophrenia. Findings show that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and …

Aug 8, 2022 · Bromodomain containing 1 (BRD1) encodes an epigenetic regulator that controls the expression of genetic networks linked to mental illness. BRD1 is essential for normal brain development and its...

Feb 17, 2025 · In our investigation, we have uncovered a novel role for BRD1 as an oncogene implicated the regulation of lipid metabolism in HCC progression. Specifically, the deficiency of BRD1 impedes the proliferation and metastasis of HCC cells reducing the accumulation of lipid droplets and cholesterol levels.

Dec 18, 2014 · Brd1 is a subunit of the Hbo1 histone acetyltransferase (HAT) complex responsible for acetylation of histone H3 at lysine 14 (H3K14). Here we show that deletion of Brd1 in haematopoietic progenitors causes variegated expression of Cd8, resulting in the appearance of CD4(+)CD8(-)TCRβ(-/low) thymocytes indistinguishable from DP thymocytes in ...