Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals [5][6][7] Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus.

BET inhibitors are a class of drugs that reversibly bind the bromodomains of Bromodomain and Extra-Terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT, and prevent protein-protein interaction between BET proteins and acetylated histones and transcription factors.

2024年12月24日 · BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include Nut Midline Carcinoma and Adolescence-Adult Electroclinical Syndrome. Among its related pathways are Gene expression (Transcription) and Autodegradation of the E3 ubiquitin ligase COP1.

In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation.

2022年6月27日 · BRD2/3/4/T是哺乳动物细胞中BET蛋白家族成员，它们均包含两个保守的溴结构域和一个ET结构域，是多种疾病抑制剂的关键靶点。 BRD4通过招募转录延伸因子pTEF-b调控PolII的转录延伸在领域内广泛报道。 但是BET家族成员BRD2如何调控Pol II 转录，其与BET蛋白家族其它成员之间的功能关系尚不清楚。 另一方面，BRD2对小鼠早期胚胎发育至关重要，然而BRD2在 干细胞 命运决定和分化中的调控机制依然未知。

2013年9月18日 · Brd2 is specifically localized at promoters of target genes, and our data show that Brd2 interaction with chromatin cannot be explained solely by histone acetylation. Using coimmunoprecipitation and live-cell imaging, we show that the C-terminal part is crucial for Brd2 association with chromatin.

Human BRD2 (originally known as RING3) and mouse Brd2 (originally known at Fsrg1) were the first mammalian BET genes discovered (Beck, Hanson, Kelly, Pappin, & Trowsdale, 1992; Rhee, Brunori, Besset, Trousdale, & Wolgemuth, 1998). Among the murine BETs, Brd2 is similar to fs(1)hS as it has no long C-terminal tail (Fig. 11.1).

该基因编码属于 BET (溴结构域和额外末端结构域) 蛋白质家族的转录调节因子。 这种蛋白质在有丝分裂过程中与转录复合物和乙酰化染色质结合，并通过其两个溴结构域选择性地结合组蛋白 H4 的乙酰化赖氨酸 12 残基。 该基因映射到染色体 6p21.3 上的主要组织相容性复合体 (MHC) II 类区域，但序列比较表明该蛋白质不参与免疫反应。 该基因与青少年肌阵挛性癫痫有关，这是一种常见的癫痫形式，在青春期变得明显。 已经描述了该基因的多个可变剪接变体。 [RefSeq 提 …

BRD2 (human BRD2, mouse Brd2) is the founding member of the BET family of double bromodomain-containing genes, which have two tandem bromodomains at the N-terminal region and an ET domain at the C-terminal side of the bromodomains. The BET family includes Brd3, Brd4, and Brdt, in addition to Brd2 [Florence and Faller, 2001].

2008年11月16日 · The human BRD2 proto-oncogene encodes a double bromodomain protein that binds to acetylated histone H4 in chromatin and is located within the MHC class II locus, suggesting Brd2 plays a role in immunity.

Human BRD2 was first identified as an autophosphorylating nuclear-specific protein in Hela extracts [1]. Recombinant BRD2 expressed in E. coli showed in vitro kinase activity. However, the kinase activity was only seen when the purified recombinant protein was first incubated with Hela cell extract and repurified.

BRD2 is considered to be an “epigenetic reader” because its bromodomains binds to acetylated histone protein, thus interpreting the epigenetic landscape and directing its parent transcriptional complexes to specific loci within the genome. You might find …

2017年4月6日 · We find that BRD2, but not BRD4, co-localizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wide. CTCF recruits BRD2 to co-bound sites whereas BRD2 is dispensable for CTCF occupancy.

Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals . Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus.

BRD2 is a chromatin reader protein that recognizes and binds acetylated histones, specifically H4K5ac and H4K12ac. This binding controls gene expression and chromatin remodeling. It recruits transcription factors and coactivators to target gene sites, activating RNA polymerase II for transcriptional elongation.

2017年3月16日 · In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation.

2007年2月9日 · BRD2 contains two bromodomains (BD1 and BD2), which are considered to be responsible for binding to acetylated chromatin. The BRD2 protein specifically recognizes the histone H4 tail acetylated at Lys 12. Here, we report the crystal structure of the N-terminal bromodomain (BD1, residues 74-194) of human BRD2.

Brd2 is a member of the bromodomain extra terminal (BET) protein family, which consists of four chromatin-interacting proteins that regulate gene expression. Each BET protein contains two N-terminal bromodomains, which recognize acetylated histones, and the C-terminal protein–protein interaction domain.

We found that the protein BRD2 is an essential node in the cellular response to SARS-CoV-2 infection. BRD2 is required for ACE2 transcription in human lung epithelial cells and cardiomyocytes, and BRD2 inhibitors currently evaluated in clinical trials potently block endogenous ACE2 expression and SARS-CoV-2 infection of human cells.

2012年9月7日 · To investigate whether Brd2 regulates neuronal differentiation through a E2F1 transcriptional factor, which directly binds Brd2 and controls genes expression for cell cycle progression and exit, we analyzed Brd2;E2F1 double mutant phenotypes and, consequently found that abnormalities in neuronal differentiation and cell cycle progression due to ...