BRD4 Gene - GeneCards | BRD4 Protein | BRD4 Antibody
2024年12月24日 · BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Cornelia De Lange Syndrome 6 and Cornelia De Lange …
BRD4 and Cancer: going beyond transcriptional regulation
2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and …
BRD4 and Cancer: going beyond transcriptional regulation
2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and …
Super-enhancers and the super-enhancer reader BRD4 ... - Nature
2023年12月22日 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce …
Regulation of programmed cell death by Brd4 | Cell Death
2022年12月20日 · Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted inhibition of Brd4 suppresses growth and induces apoptosis of various …
Emerging roles of and therapeutic strategies targeting BRD4 in …
These findings provide insight into the role of BRD4 in epigenetic regulation of gene pathways that promote the metastatic phenotype of cancer cells and suggest that therapies targeting BRD4 …
BRD4 - an overview | ScienceDirect Topics
BRD4 is a member of the BET family of bromodomains that act as genetic readers of histone acetyl lysine residues to regulate gene transcription. BRD4 has become a popular epigenetic …
BRD4 Inhibitor in Cancer Treatments: Mechanisms and Impact
2 天之前 · BRD4’s role in cancer extends beyond transcriptional regulation, integrating multiple oncogenic pathways that drive tumor progression. Its ability to sustain oncogene expression …
Phosphorylation by JNK switches BRD4 functions - Cell Press
2024年11月21日 · JNK-mediated BRD4 functional switching induces CD8 expression in thymocytes and epithelial-to-mesenchymal transition (EMT) in prostate cancer cells. These …
Discovery of dual CDK4/6 and BRD4 inhibitor as ... - ScienceDirect
5 天之前 · BRD4 is a member of the BET family for bromodomain proteins, specifically recognizes histone H3 and H4 acetylated lysines and plays a crucial role in cellular transcriptional …
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