Bromodomain-containing protein 4 (BRD4) as an epigenetic
2022年10月29日 · In this study, BRD4-binding proteins were obtained through co-immunoprecipitation (Co-IP) and mass spectrum (MS) to identify the co-regulators with BRD4 …
Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation …
2023年9月22日 · To determine which PRMTs methylated BRD4, we assessed the potential interactions between PRMTs (PRMT1, PRMT2, PRMT3, PRMT4, PRMT5, and PRMT9) and …
Brd4 binds to active enhancers to control cell identity gene …
2017年12月20日 · Using two conditional knockout mouse strains and derived cells, we demonstrate that Brd4 controls cell identity gene induction and is essential for adipogenesis …
The Bromodomain Protein 4 Contributes to the Regulation of …
2019年11月11日 · The bromodomain protein 4 (BRD4) is an atypical kinase and histone acetyl transferase (HAT) that binds to acetylated histones and contributes to chromatin remodeling …
Distinct layers of BRD4-PTEFb reveal bromodomain ... - Cell Press
2023年8月17日 · Although BRD4-PTEFb can associate with chromatin through acetyl recognition, our results indicate that a distinct, active BRD4-PTEFb population functions to regulate …
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 …
2025年1月3日 · We found that targeted inhibition of bromodomain-containing protein 4 (BRD4) by siRNA or its inhibitor (JQ1) significantly decreases mRNA m 6 A levels and suppresses the …
BRD4蛋白研究新发现——助力治疗包括癌症在内的多种疾病 - 知乎
brd4 是一种转录和表观遗传调节因子，在胚胎发生和癌症发展过程中起着关键作用。作为溴结构域和末端外结构域 (bet) 家族的成员，brd4 的特征在于具有两个串联溴结构域（bd1、bd2） …
BRD4缺失通过GRP78灭活内质网应激，延缓脱氢表雄酮诱导的卵 …
2025年2月27日 · 近日，一项由宁波大学医学院附属妇女儿童医院与同济大学附属东方医院妇产科合作的研究，揭示了BRD4（Bromodomain-containing protein 4）在PCOS中的重要作用，以 …
厦门大学生命科学学院团队揭示BRD4调控m6A甲基转移酶复合体 …
近日，尤涵教授研究团队在PNAS上发表题为A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair–targeted therapy的研 …
Phospho Switch Triggers Brd4 Chromatin Binding and Activator ...
2013年3月7日 · Using purified proteins for individual incubation with recombinant FLAG-tagged human Brd4 (f:Brd4) and followed by immunoprecipitation (IP) with anti-Brd4 antibody and …