RNAi screen identifies Brd4 as a therapeutic target in acute …
2011年8月3日 · By screening a custom library of small hairpin RNAs (shRNAs) targeting known chromatin regulators in a genetically defined AML mouse model, we identify the protein …
BRD4-mediated repression of p53 is a target for combination
2021年1月11日 · Here, we report enhanced toxicity of combined MDM2i and BETi towards AML cell lines, primary human blasts and mouse models, resulting from BETi’s ability to evict an …
Targeting BRD4 in acute myeloid leukemia with partial tandem ...
Targeting BRD4/Brd4 using the inhibitor JQ1 has an effect on MLL-partial tandem duplication (MLL-PTD)/Mll-PTD acute myeloid leukemia cells. (A) WST-1 assay on EOL-1 and K562 cells …
Functional interdependence of BRD4 and DOT1L in MLL leukemia
2016年6月13日 · Using quantitative proteomics, chemoproteomics and biochemical fractionation, we found that native BRD4 and DOT1L exist in separate protein complexes. Genetic …
Functional interdependence of BRD4 and DOT1L in MLL leukemia
2016年6月16日 · Using quantitative proteomics, chemoproteomics and biochemical fractionation, we found that native BRD4 and DOT1L exist in separate protein complexes. Genetic …
BRD4 associates with p53 in DNMT3A-mutated leukemia cells and …
The bromodomain and extra terminal (BET) family protein bromodomain containing protein 4 (BRD4) is an epigenetic regulator recently identified as a therapeutic target for several …
BRD3/4 inhibition and FLT3-ligand deprivation target pathways …
We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in vivo efficacy of the BRD3/4 inhibitor …
Targeting BRD4 in acute myeloid leukemia with partial tandem ...
2021年9月1日 · Targeting BRD4 in acute myeloid leukemia with partial tandem duplication of the MLL gene Haematologica . 2021 Sep 1;106(9):2527-2532. doi: 10.3324/haematol.2020.271627.
Targeting BRD4 in acute myeloid leukemia with partial tandem ...
Targeting BRD4/Brd4 using the inhibitor JQ1 has an effect on MLL-partial tandem duplication (MLL-PTD)/Mll-PTD acute myeloid leukemia cells. (A) WST-1 assay on EOL-1 and K562 cells …
BRD4拮抗剂GSK525762A抗普通型急性B淋巴细胞白血病的体外研 …
探讨4型含Bromo结构域蛋白（BRD4）拮抗剂对普通型急性B淋巴细胞白血病（B-ALL）患者原代白血病细胞的作用及可能机制。 采用流式细胞术分选14例普通型B-ALL患者（Ph + B-ALL 4 …