2023年7月17日 · A BRIP1 mutation increases your risk for ovarian cancer. A BRIP1 mutation may also increase your risk for breast cancer, but more research is needed for us to better understand this risk. While a BRIP1 mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives ...

BRIP1 protein is a DNA helicase that is employed in homologous recombinational repair, and in the response of the cell to DNA replication stress. [11] In part, BRIP1 carries out its function through interaction with other key DNA repair proteins, specifically MLH1, BRCA1 and BLM. [11]

2024年2月25日 · An inherited BRIP1 mutation may affect your options for fallopian tube and ovarian cancer prevention, detection and treatment. FORCE is here to guide you.

2024年12月24日 · BRIP1 (BRCA1 Interacting DNA Helicase 1) is a Protein Coding gene. Diseases associated with BRIP1 include Fanconi Anemia, Complementation Group J and Breast Cancer. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).

BRIP1 Mutation is a predictive biomarker for use of olaparib in patients. Of the therapies with BRIP1 Mutation as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.

2024年9月6日 · People with an inherited BRIP1 mutation have an increased risk for cancer. Read about medical options for lowering cancer risk or detecting it early. FORCE is here to guide you.

4 天之前 · People with a BRIP1 mutation have a 5-15% lifetime risk of fallopian tube, ovarian or primary peritoneal cancer. These three cancers are related and are often referred to together as ovarian cancer.

brip1 基因突变会增加罹患卵巢癌的⻛险。 BRIP1 突变也可能会增加罹患乳腺癌的⻛ 险，但我们还需要进⾏更多研究才能更好地了解这种⻛险。

What is my cancer risk if I have a BRIP1 mutation? A BRIP1 mutation increases your risk for ovarian cancer. A BRIP1 mutation may also increase your risk for breast cancer, but more research is needed for us to better understand this risk. While a BRIP1 mutation means you have a somewhat higher risk of

2025年3月8日 · Dominant-negative pathogenic variant BRIP1 c.1045G>C is a high-risk allele for non-mucinous epithelial ovarian cancer: A case-control study. BRIP1 rs10744996C>A variant increases the risk of chronic obstructive pulmonary disease in the Mongolian population of …