Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor …
2015年7月14日 · This study shows that through a targeted regulation of surface BST2, Vpu promotes HIV-1 release and limits pDC antiviral responses upon sensing of infected cells. This …
LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin ...
2016年11月22日 · Here, we investigate whether the autophagy pathway and/or ATG proteins are hijacked by HIV-1 Vpu to circumvent BST2 restriction of viral release. We report that BST2 …
Ubiquitination of BST-2 Protein by HIV-1 Vpu Protein Does Not …
2012年4月4日 · Results: Vpu targets BST-2 for ubiquitination, and this does not require the BST-2 cytoplasmic Lys, Ser, or Thr residues. Conclusion: BST-2 is degraded within the lysosome as …
Vpu and BST2: Still Not There Yet? - PubMed
2012年4月9日 · In this review, we particularly focus on the interplay between Vpu and BST2. We discuss the possibility that Vpu has evolved as a potent antagonist against BST2, and finally, …
Efficient BST2 antagonism by Vpu is critical for early HIV-1 ...
2013年11月6日 · Vpu is a multifunctional accessory protein that enhances the release of HIV-1 by counteracting the entrapment of nascent virions on infected cell surface mediated by …
Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release
2009年5月29日 · Here, we show that the optimal removal of BST-2 from the plasma membrane by Vpu requires the cellular protein β-TrCP, a substrate adaptor for a multi-subunit SCF E3 …
Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu ...
Here we provide evidence that under physiological conditions, BST-2 is preferentially targeted by Vpu over NTB-A and PVR. Specifically, we show that type I IFNs decrease Vpu’s …
Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu ...
2019年6月18日 · Here we provide evidence that under physiological conditions, BST-2 is preferentially targeted by Vpu over NTB-A and PVR. Specifically, we show that type I IFNs …
Efficient BST2 antagonism by Vpu is critical for early HIV-1
2013年11月6日 · Results: Using a humanized mouse model of acute infection as well as CCR5-tropic HIV-1 that lack Vpu or encode WT Vpu or Vpu with mutations in the β-TrCP binding …
A novel peptide to disrupt the interaction of BST-2 and Vpu
In this study, we designed and prepared a modified peptide BST2-TM-P1, which include the sequence of BST-2 TMD, keeping its property competing with BST-2 to bind with Vpu. …
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