近日，美国弗吉尼亚理工大学的研究人员在 Nature 子刊 Nature Communications 杂志发表题为：Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice 的研究论文。 该研究发现一种名为BAM15的小分子药物，可以在不影响食物摄入量、肌肉质量以及体温的情况下降低小鼠的体内脂肪量。 此外，该分子有利于降低胰岛素抵抗、氧化应激和炎症，为肥胖症、糖尿病，特别是非酒精性脂肪性肝炎(NASH)的治疗和预防带来了希望。 研究统计显 …

2023年10月11日 · By disrupting the coupling between electron transport and ATP synthesis, BAM15 dissipates the proton gradient, leading to increased mitochondrial respiration and energy expenditure. This review provides a comprehensive overview of BAM15, including its mechanism of action and potential therapeutic applications in diverse disease contexts.

2023年10月11日 · BAM15 是一种选择性线粒体解偶联剂，由于其增强线粒体呼吸和代谢灵活性的能力，已成为一种有前途的治疗剂。 通过破坏电子传输和 ATP 合成之间的耦合，BAM15 消除了质子梯度，导致线粒体呼吸和能量消耗增加。

2023年10月11日 · AMPK responds to BAM15-induced ATP reduction, facilitating glucose uptake and fatty acid oxidation. Concurrently, BAM15 enhances PGC-1α activity, promoting upregulation of genes related to mitochondrial biogenesis. Additionally, BAM15 mitigates tissue damage and inflammation by modulating mtDNA/mtROS release and macrophage polarization.

2023年2月9日 · BAM15, a chemical uncoupler, dissipates mitochondrial proton gradients without generating mtROS. We injected BAM15 into mice at 0, 6, or 12 hours after cecal ligation and puncture (CLP), and these mice were treated with fluids and antibiotics.

2023年2月9日 · We found that (a) BAM15 improved survival and AKI after sepsis, even with a 12-hour treatment delay; (b) levels of 1 DAMP, mtDNA, were diminished by BAM15 treatment in vivo and in vitro; (c) mtDNA caused tissue and cell injury that were reversed by BAM15; (d) BAM15 reduced kidney injury by reducing neutrophil infiltration and tubule ROS/RNS ...

2014年4月1日 · Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less cytotoxic. Furthermore, BAM15 is bioactive in vivo and dose-dependently protects mice from acute renal ischemic-reperfusion injury.

BAM15是一种可口服的新的线粒体特异性质子载体解偶联剂，在增加能量消耗方面显示出与DNP相似的效力，此外，BAM15可以增加营养物质的氧化，并在不改变食物摄入量、瘦体重、体温或血液毒性标志物的情况下降低体脂肪量。

2013年11月28日 · Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less cytotoxic. Furthermore, BAM15 is bioactive in vivo and dose-dependently protects mice from acute renal ischemic-reperfusion injury.

BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells (A10 cells). BAM15 relaxed phenylephrine (PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium.