三阴性乳腺癌及其分子亚型分型 - 知乎 - 知乎专栏
2020年12月29日 · TNBC在基因表达层面上是一组混合型乳腺癌，可以细分为6个分子亚型： 基底样-1型 （basal-like-1,BL-1）, 基底样-2型 （basal-like-2,BL-2）， 免疫调节型 （immunomodulatory,IM），间质性（mesenchymal,M）, 间质干细胞型 （mesenchymal stem-like,MSL）及雄激素受体型（lumial androgen ...
Basal-like and triple-negative breast cancers: a critical ... - Nature
2010年11月12日 · Histologically, the majority of basal-like breast cancers is of IDC-NST type, high histological grade, and characterized by exceptionally high mitotic indices, the presence of central necrotic or...
Basal Breast Cancer: A Complex and Deadly Molecular Subtype
The basal subtype represents a challenging subtype with distinctive epidemiological, histoclinical, and molecular features, with distinctive patterns of relapse, poor prognosis despite relative chemosensitivity, and no available targeted therapy.
Immunohistochemical characteristics of basal-like breast cancer
Patients with diagnosed basal-like subtype have the most serious prognosis. The microarray method is not routine in clinical diagnosis of breast cancer. Currently immunohistochemical staining is a basic method in the pathological diagnosis of breast cancer.
Deep learning-based classification of breast cancer molecular subtypes …
2025年1月1日 · Broadly, breast cancer has four molecular subtypes: luminal A (LumA), luminal B (LumB), HER2-enriched (HER2), and basal-like (BL). Normally, BL tumors exhibit higher rates of recurrence during the initial 5 years following detection and treatment, but they show higher response to chemotherapy.
Molecular stratification within triple-negative breast cancer subtypes
2019年12月13日 · Triple-negative breast cancer (TNBC) has been subdivided into six distinct subgroups: basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem–like (MSL), immunomodulatory...
Biological subtypes of breast cancer: Prognostic and therapeutic ...
Basal-like. The basal-like subtype represents from 8% to 37% of all breast cancers, depending on the proportion of poorly differentiated G3 cases included in the population studied.
Basal breast cancer: a complex and deadly molecular subtype
The basal subtype, which represents 15-25% of cases, is characterized by an expression profile similar to that of myoepithelial normal mammary cells. Basal tumors are frequently assimilated to triple-negative (TN) breast cancers. They display epidemiological and clinico-pathological features distinct from other subtypes.
Differential chromatin accessibility and transcriptional dynamics ...
2024年10月30日 · Genome-wide expression profiling identified five biological BC subtypes 36, namely luminal A/B, HER2-enriched, basal-like and normal breast-like, which differ by hormonal receptor status ...
乳腺癌分子分型 - 简书
2020年5月13日 · HER2指的是erb-B2（酪氨酸激酶受体2，又名NEU, CD340原癌基因erbB-2编码的185kDa的细胞膜受体，为表皮生长因子受体 (epidermal growth factor receptor，EGFR)家族成员之一。 该家族包括erb-B1 (又称EGFR，HER1)、erb-B2 (又称HER2)、erb-B3 (HER3)和erb-B4 (HER4)四个成员。