Blood-brain barrier disruption (BBBD) is a consequence of ischemia and may also exacerbate damage to brain parenchyma. Therefore, maintaining BBB integrity is critical for the central nervous system …

2019年4月11日 · We propose BBBD mapping as a valuable tool for detection of subtle brain ischemia and a promising predictive biomarker required for risk stratification and stroke prevention.

2018年6月1日 · Detection and localization of the early phase of blood–brain barrier disruption (BBBD) in vivo during cerebral ischemia/reperfusion injury remain a major challenge but may be a relevant outcome parameter in stroke.

2020年9月18日 · Investigations into its BBBD potential began on the basis that adenosine is known to mediate BBB permeability, and regadenoson was shown to increase brain concentrations of various agents including TMZ in rats , an effect likely mediated by decreased expression of tight junction proteins and vasodilation (38, 39).

Osmotic blood-brain barrier disruption (BBBD) therapy was first introduced in the early 1980s as a method to increase the penetration of chemotherapeutics into the central nervous system (CNS). 1,2 The procedure involves intra-arterial injection of a warmed, hypertonic mannitol solution to disrupt the tight junctions of vascular endothelial ...

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