PDH（EC 4.1.1.1）广泛存在于动物、植物、微生物和培养细胞中，是丙酮酸脱氢酶复合体 (PDHC)催化丙酮酸氧化脱羧的限速酶，催化丙酮酸脱梭生成羟乙基-TPP，把糖酵解和三羧酸循环连接起来。 PDH 催化丙酮酸脱氢，同时还原 2,6-二氯酚靛酚（2,6-DCPIP），从而导致 605nm 光 …

2018年6月22日 · PDH senses intermediate metabolites —such as pyruvate and acetyl-CoA— and the NAD + /NADH redox state to control glucose metabolism and maintain optimal energy homeostasis 32.

6 天之前 · Pyruvate Dehydrogenase Antibody detects endogenous levels of total α1 and α2 subunits of pyruvate dehydrogenase protein. Human, Mouse, Rat, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequences of both α1 and α2 subunits of human pyruvate dehydrogenase.

2017年11月13日 · Our study uncovers a noncanonical thermogenic mechanism through which beige fat controls whole-body energy homeostasis via Ca 2+ cycling. UCP1 is a mitochondrial protein specific to brown adipose...

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In the absence of UCP1, however, we found that beige adipocytes dynamically expend glucose and generate ATP through enhanced glycolysis, TCA metabolism, and PDH activity for ATP-dependent thermogenesis by Ca 2+ cycling. This metabolic rewiring towards glucose oxidation is highly dependent on the SERCA2b-RyR2 pathway and this enhancement ...

目前已经工业化的丙烯生产途径主要包括石脑油蒸汽裂解、炼油副产、重烯烃（C4~C8）转化、甲醇制丙烯（MTP）以及丙烷脱氢（PDH）。 其中，前两个是目前获得丙烯的传统工艺和主要途径，其他则是一些新兴工艺。 近几年，世界以及国内PDH产业蓬勃发展，加上页岩气的开发带来的大量丙烷副产物，PDH工艺将迎来绝好机遇，PDH对丙烯的贡献比例也将不断增大。 目前，可供工业化的PDH工艺主要有5种，详见下表。 丙烷脱氢包括直接脱氢（PDH）和氧化脱 …

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2020年4月1日 · PDH is a rare enzyme found only in a narrow group of fungi (Agaricaceae). PDH has a remarkably broad substrate specificity for the electron donor (sugar) substrate. PDH is capable of oxidizing the substrate in more than one position. PDH with a C1-specific enzyme yields up to six electrons per substrate molecule.