What is a beta-2 microglobulin tumor marker test? A beta-2 microglobulin tumor marker test measures the amount of a protein called beta-2 microglobulin (B2M) in your body fluids. The test usually uses a sample of your blood. It may also be done using urine (pee) or in rare cases cerebrospinal fluid (CSF). B2M is a type of tumor marker.

β 2 microglobulin (B2M) is a component of MHC class I molecules. MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excluding red blood cells). [5] [6] In humans, the β 2 microglobulin protein [7] is encoded by the B2M gene. [6] [8]

2023年6月8日 · Beta-2 microglobulin (B2M) is a biomarker protein found on the surface of cells, including lymphocytes, and in bodily fluids. B2M is considered a tumor marker because high levels of the antigen may be indicative of certain cancers. In normal biological functioning, B2M is synthesized, excreted and reabsorbed back into the body.

2024年1月30日 · 本文将探讨β2微球蛋白的结构、功能以及其在疾病诊断中的应用。 β2微球蛋白是 主要组织相容性复合体 （MHC）类I分子的重要组成部分。 它与 MHC类I分子 的α链非共价结合，帮助稳定MHC类I分子的结构并促进其正确折叠。 这种结合对于将细胞内产生的肽段呈递给免疫系统的 CD8+ T细胞 至关重要，是免疫监视机制中不可或缺的一环。 β2微球蛋白使MHC类I分子能够有效地呈现肽段给CD8+ T细胞，这一过程对于识别和清除体内的病毒感染细胞和肿瘤细胞 …

β2微球蛋白（英語： β 2-microglobulin ，缩写B2M）是MHC1類分子分子的组成部分之一，在所有有核的细胞中（即不包括红细胞）都有表达 [6] [7] 。 在人类基因组中，β2微球蛋白 [ 8 ] 由 B2M 基因 所编码 [ 7 ] [ 9 ] 。

β2-微球蛋白 （Beta-2-microglobulin , β2-MG），是细胞表面 人类淋巴细胞抗原 （HLA）的β链（轻链）部分，分子质量为11.8kD，由99个氨基酸组成的单链多肽，主要由淋巴细胞、血小板、多形核白细胞产生。

2020年9月24日 · Beta 2 microglobulin is shed from the surface of nucleated cells into serum; increased levels can be seen in a wide variety of disorders that involve increased cell turnover and/or activation of...

2024年12月24日 · B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Hereditary Systemic 6. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include identical protein binding.

β2M is critical for the immune surveillance and modulation in vertebrate animals. The dysregulation of β2M is associated with multiple diseases, including endogenous and infectious diseases. β2M could directly participate in the development of cancer cells, and the level of β2M is deemed as a prognostic marker for several malignancies.

2021年6月13日 · Beta2-microglobulin (B2M) a key component of major histocompatibility complex class I molecules, which aid cytotoxic T-lymphocyte (CTL) immune response. However, the majority of studies of B2M have focused only on amyloid fibrils in pathogenesis to the neglect of its role of antimicrobial activity.