Diagnosis of ketosis associated with DKA can be difficult due to variability in the metabolic state of DKA patients. Recognition of the clinical signs and definitive diagnosis are essential for proper treatment. This article reviews the formation of ketoacids during DKA and the role of β-hydroxybutyric acid in the diagnosis and monitoring of DKA.

2021年8月6日 · A strongly elevated beta-hydroxybutyrate level would support a diagnosis of DKA. A markedly elevated lactate level with mildly elevated beta-hydroxybutyrate level might suggest an underlying disease process (e.g., sepsis or shock) that may be causing a …

2005年5月1日 · Beta-hydroxybutyrate is a better measurement of the degree of ketosis than serum ketones. Intravenous insulin and fluid replacement are the mainstays of therapy, with careful...

Diabetic ketoacidosis (DKA) is a common emergency department (ED) presentation of both new-onset and established diabetes mellitus (DM). β-hydroxybutyrate (BOHB) provides a direct measure of the pathophysiologic derangement in DKA as compared to the ...

2008年4月1日 · CONCLUSIONS —Where available, serum βOHB levels ≥3.0 and ≥3.8 mmol/l in children and adults, respectively, in the presence of uncontrolled diabetes can be used to diagnose DKA and may be superior to the serum HCO 3 level for that purpose.

Over 6 months, 404 patients with diabetes had at least one beta-hydroxybutyrate level measured in the emergency department. There were 23 admissions for diabetic ketoacidosis (DKA) or hyperosmolar state.

2023年7月10日 · In acute DKA, the ketone body ratio (3-beta-hydroxybutyrate:acetoacetate) rises from normal (1:1) to as high as 10:1. In response to insulin therapy, 3-beta-hydroxybutyrate (3-HB) levels commonly decrease long before acetoacetate (AcAc) levels.

6 天之前 · Diagnosis. The diagnosis of DKA requires the presence of 3 criteria: (1) diabetes or hyperglycemia (D criterion), with a glucose level of 200 mg/dL or greater or a prior history of diabetes; (2) ketosis (K criterion), with a beta-hydroxybutyrate level of 3.0 mmol/L or greater or urine ketones at 2+ or higher; and (3) metabolic acidosis (A criterion), with pH less than 7.3, a …

2023年8月8日 · Ketoacidosis is a metabolic state associated with pathologically high serum and urine concentrations of ketone bodies, namely acetone, acetoacetate, and beta-hydroxybutyrate. During catabolic states, fatty acids are metabolized to ketone bodies, which can be readily utilized for fuel by individual cells in the body.

2021年12月1日 · β-Hydroxybutyrate accurately predicts DKA in children and adolescents. More importantly, because plasma BOHB is the ideal biochemical marker of DKA, BOHB may provide a more optimal definition of DKA for management decisions and treatment targets.