One of the main anti-inflammatory response mediators is bikunin (Bik) that is responsible for inhibiting the activity of many serine proteases such as trypsin, thrombin, chymotrypsin, …

2000年2月1日 · It was recently discovered, however, that bikunin effectively inhibits a proteinase that seems to be involved in the metastasis of tumour cells — cell surface plasmin — and that …

2011年10月9日 · Bikunin, the simplest proteoglycan, with a single glycosaminoglycan chain, is a serine protease inhibitor used to treat acute pancreatitis. Unlike nucleic acids and proteins, …

2007年1月1日 · Bikunin (Bik), a peptide excreted in the urine, is one of the primary inhibitors of the trypsin family of serine proteases. This peptide plays a key role in inflammation and innate …

双库尼茨抑制剂是一种化学分子式，属于生物化学与分子生物学。 分子中含有两个库尼茨 (Kunitz)型的 胰蛋白酶抑制剂 结构域，即一个抑制剂分子可以结合二分子的胰蛋白酶，是一种 …

2022年11月21日 · Bikunin is a small chondroitin sulfate proteoglycan (PG) with Ser-protease inhibitory activity that plays pleiotropic roles in health and disease. It is involved in several …

The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the …

Inter-α-trypsin inhibitor (IαI) family members are ancient and unique molecules that have evolved over several hundred million years of vertebrate evolution. IαI is a complex containing the …

Bikunin可以通过抑制尿激酶型纤溶酶原激活剂 (uPA)、调节有关信号传导途径等机制抑制卵巢癌的浸润和转移.裸鼠体内实验已证实Bikunin的治疗作用.临床观察表明Bikunin水平与卵巢癌患者预 …

2020年6月24日 · Bikunin, a chondroitin sulfate (CS) proteoglycan clinically used to treat acute inflammation and sepsis, contains a CS chain with more than 20 monosaccharide units. To …