Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene. [5][6] This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein …

2024年12月24日 · BIRC6 (Baculoviral IAP Repeat Containing 6) is a Protein Coding gene. Diseases associated with BIRC6 include Autism Spectrum Disorder and Brain Cancer. Among …

Here we show that BIRC6 forms an anti-parallel U-shaped dimer with multiple previously unannotated domains, including a ubiquitin-like domain, and the proapoptotic factor …

Northern blot analysis revealed ubiquitous expression of a 15-kb transcript. Of 38 human cancer cell lines examined by Western blot analysis, BIRC6 was expressed as a 530-kD protein in 4 …

2017年3月14日 · Here, we examined whether BIRC6, an IAP family member, has a role in enzalutamide resistance of CRPCs and could provide a therapeutic target for enzalutamide …

2012年9月4日 · BIRC6 (a.k.a. APOLLON, BRUCE) is an exceptionally large protein of 528 kDa belonging to the family of inhibitor of apoptosis (IAP). BIRC6 contains one bacalovirus IAP …

2022年8月30日 · We show BIRC6 is an antiparallel homodimer that forms a crescent shape that arcs around a spacious cavity. The cavity is surrounded by binding sites for client proteins, …

2023年2月21日 · Researchers from Nuffield Department of Medicine, Department of Biochemistry and CAMS Oxford Institute uncover how BIRC6 (a giant ubiquitin ligase) protects cells from …

2014年10月1日 · BIRC6 is a peripheral membrane protein of the trans-Golgi network that protects cells from apoptosis by functioning as an inhibitor of apoptosis protein (IAP). BIRC6 can bind …

2022年12月11日 · Here we show that BIRC6 forms an anti-parallel U-shaped dimer in a 3.6-Å cryo-EM structure with multiple previously unannotated domains, including a ubiquitin-like …