Immunity:RIPK1与RIPK3介导细胞炎症反应机制 - 搜狐
2016年7月20日 · RIPK1 and RIPK3 are homologous kinases, previously linked to activation of necroptotic death. In this study, we have described roles for these kinases as master …
RIPK3 promotes cell death and NLRP3 inflammasome activation …
2015年2月18日 · Here we show that following LPS treatment, or LPS-induced necroptosis, the TLR adaptor protein TRIF and inhibitor of apoptosis proteins (IAPs: X-linked IAP, cellular IAP1 …
Immunity：RIPK1与RIPK3介导细胞炎症反应机制 - 梅斯医学MedSci
RIPK3能够与RIPK1结合形成“坏死性小体”这一结构能够导致下游MLKL的激活，后者是细胞裂解与坏死的关键调节因子。 与RIPK1、RIPK3引发的细胞死亡信号通路不同，目前有一些研究也表 …
RIPK3 collaborates with GSDMD to drive tissue injury in lethal
2020年3月9日 · In this study, we found that blockage of both necroptosis and pyroptosis (double deletion of Ripk3 / Gsdmd or Mlkl / Gsdmd) resulted in accumulative protection against septic …
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent …
2016年7月19日 · RIPK1 and RIPK3 are homologous kinases, previously linked to activation of necroptotic death. In this study, we have described roles for these kinases as master …
RIPK3: Beyond Necroptosis: Immunity - Cell Press
2019年1月15日 · Importantly, the described RIPK3 antiviral pathway is specific to neurotropic flavivirus infections, and the authors show that RIPK3 does not function to control itaconate …
RIPK3 Activation Leads to Cytokine Synthesis that Continues after …
2019年8月27日 · Here, we report that cells undergoing necroptosis in response to direct RIPK3 activation or viral infection continue de novo synthesis of cytokines and chemokines for …
RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent ...
2017年4月6日 · Using a mouse model of West Nile virus (WNV) encephalitis, we show that RIPK3 restricts WNV pathogenesis independently of cell death. Ripk3−/− mice exhibited enhanced …
Autophagy regulates inflammatory programmed cell death via
2019年7月9日 · RIPK1, RIPK3, ZBP1 and TRIF, the four mammalian proteins harboring RIP homotypic interaction motif (RHIM) domains, are key components of inflammatory signaling …
RIP3 induces apoptosis independent of pro-necrotic kinase activity
Receptor interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three selective small …