Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. [5] BMP-2 like other bone morphogenetic proteins, [6] plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine -cytokine receptor interaction.

Bone Morphogenetic Protein 2 (BMP-2) is a ligand protein with pleiotropic, belongs to TNFβ family. BMP-2 formats BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development [1].

BMP-2 has important roles during embryonic development, as well as bone remodeling and homeostasis in adulthood. Some of its specific functions include digit formation and activating osteogenic genes, such as Runt-Related Transcription Factor 2 (RUNX2).

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in extracts derived from bone, are now known to play important roles in a wide array of processes during formation and maintenance of various organs including bone, cartilage, muscle, kidney, and blood vessels.

骨形态发生蛋白-2（bone morphogenetic protein-2，BMP-2） 是转化生长因子B超家族成员之一，具有诱导未分化间充质干细胞向成软骨细胞和成骨细胞定向分化与增殖能力，促进成骨细胞分化成熟，参与骨和软骨生长发育及其重建过程，进而加速骨缺损修复.BMP-2在体内以前 ...

2024年12月24日 · BMP2 (Bone Morphogenetic Protein 2) is a Protein Coding gene. Diseases associated with BMP2 include Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies 1 and Brachydactyly, Type A2. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

2020年9月13日 · BMP-2 has important roles during embryonic development, as well as bone remodeling and homeostasis in adulthood. Some of its specific functions include digit formation and activating osteogenic genes, such as Runt-Related Transcription Factor 2 (RUNX2).

2025年1月4日 · BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells. Zhou N, et al. Cell Tissue Res, 2016 Oct. PMID 27083447. Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1.

1999年3月12日 · Homodimeric bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor beta (TGF-beta) superfamily that induces bone formation and regeneration, and determines important steps during early stages of embryonic development in vertebrates and non-vertebrates.

2011年12月31日 · Bone Morphogenetic Protein 2 (BMP-2) is a growth factor that induces bone formation and is used in orthopaedic surgery for bone fusions and nonunions, as well as in oral and maxillofacial surgery and implant dentistry.