Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. [5] GDF2 belongs to the transforming growth factor beta superfamily .

BMP-9 is a vascular quiescence factor maintaining endothelial homeostasis [1]. BMP-9 binds to ALK1 with a very high affinity (K d: 29 nM). BMP-9 is mainly produced by the liver, specifically by hepatocytes, and at a lower level by the lungs and the brain …

2024年1月31日 · Bone morphogenetic protein 9 (BMP9) is a cytokine in the transforming growth factor-β superfamily. Here, circulating BMP9 concentrations were quantified in two independent cohorts of patients with sepsis. Decreased concentrations of serum BMP9 were observed in the patients with sepsis at the time of admission as compared with healthy controls.

2023年6月19日 · 骨形态发生蛋白（bone morphogenetic protein，BMP）-9属于BMP家族，具有介导间充质干细胞、肌肉细胞和前成骨细胞等成骨分化的能力，还可以促进软骨形成。 BMP-9诱导成骨分化的机制与传统的骨形态发生蛋白（BMP-2、BMP-4、BMP-7 等）不完全相同。 BMP-9诱导间充质干细胞成骨分化的能力明显强于其余BMP（如BMP-2、BMP-4、BMP-7等）。...

骨形态发生蛋白 (BMP)-9，又名生长分化因子2 (GDF2)，是BMP家族中最新发现和极具成骨潜力的骨形成生长因子，已被广泛应用于骨组织工程。 BMP触发的Smad细胞信号通路通常被Noggin抑制，而BMP-9对Noggin具有抗性，进一步促进骨祖细胞向前成骨细胞分化。 本综述拟讨论BMP-9在成骨中的信号转导方式以及在骨组织工程中用于基因治疗的进展，并分析BMP-9在骨损伤修复方面中的应用和发展方向。 引用本文: 张俊河, 马静, 梁卓, 等. 骨形态发生蛋白-9在骨再生中的应用 …

2021年7月6日 · 人骨形成蛋白9 (BMP-9)又称生长分化因子2 (GDF-2)，是转化生长因子β超家族蛋白BMP亚群的一员，通过由Ⅰ型和Ⅱ型BMP受体组成的异二聚体复合物传递信号。 BMP-9调节多种胚胎和成体组织的发育和功能。 BMP-9由肝脏非实质细胞合成分泌，它能促进脂质代谢并抑制葡萄糖生成。 在胚胎中枢神经系统中，BMP-9在胆碱能神经元表型的发育和维持中起着重要作用。 BMP-9也诱导间充质干细胞分化为软骨细胞系。 在低浓度时，BMP-9是造血祖细胞的增殖因 …

2008年2月28日 · Recently, we reported that bone morphogenetic protein (BMP)9 and BMP10 are specific ligands for ALK1 that potently inhibit microvascular endothelial cell migration and growth. These data lead us to suggest that these factors may …

2023年8月3日 · Bone morphogenetic protein (BMP)-9 is considered a member of the transforming growth factor (TGF)β superfamily. It was first found as an inducer of bone and cartilage formation and then discovered that this factor mediates several physiologic functions and hemostasis.

骨形态发生蛋白 (bmp)-9 被认为是转化生长因子 (tgf)β 超家族的成员。 它首先被发现是骨和软骨形成的诱导剂，然后发现该因子介导多种生理功能和止血。

According to recent studies, BMP-9 is known to be the most potent inducer of the osteogenic differentiation of mesenchymal stem cells, both in vitro and in vivo. However, its exact role in the skeletal system is still unclear.