In particular, two studies that analyzed CD34 expression in uncultured human bone marrow nucleated cells found that MSC (BMSC) existed in the CD34 (+) fraction. Several studies have also found that freshly isolated adipose-derived MSC (ADSC) express CD34.

作为寻找间充质基质/干细胞(mesenchymal stromal/stem cells，MSC)可靠标志物的实验研究的一部分，Stro-1抗体是利用人CD34+骨髓细胞脾内免疫小鼠产生的几株杂交瘤中的一株产生的。

2022年8月29日 · 1、BMSC用于治疗膝关节软骨损伤，患者疼痛显著降低，膝关节功能指数显著改善，而软骨损伤显著减少。 2、MSC可以抑制GVHD（移植物抗宿主反应），能够促进造血干细胞植入，降低细胞或器官移植后的免疫排斥反应。 3、诱导分化：成骨、成软骨、成脂. ①成骨：同其他组织器官一样，骨组织也在不断地进行着细胞代谢，称为骨代谢。 成骨分化是骨生成的关键步骤，即骨髓间充质干细胞经历骨原细胞、成骨前体细胞、成熟的骨细胞和终末阶段的骨细胞的 …

2015年11月1日 · CD34 is a selective marker for prospective isolation of osteoprogenitor cells from expanded mBMSC. Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) and their progenitors have been identified based on retrospective functional criteria.

Results: The injection of BMSC or BMSC-Exo enhanced locomotor performance reflected by Basso, Beattie & Bresnahan score ( p < 0.001), and neuronal viability reflected by NeuN ⁺ cells ( p <...

2007年1月1日 · We could show that MSC can be isolated from at least two different fractions of BM cells, the CD45 − CD34 − and CD45 + CD34 + fractions. BM samples were obtained from consenting healthy adult donors (ages 18–35 years, both genders) by puncture of the iliac crest.

Representative expression of BMSC surface markers CD29, CD90, CD44, CD45, CD11 and CD34 as analyzed by flow cytometry. BMSCs were observed to hyperexpress CD29 (97.7%), CD90 (99.2%) and CD44...

FACS analysis of the non-sorted primary mBMSCs, sorted CD34 − and CD34 + for known BMSC markers. The isotype controls represented in red line histogram, dark blue for the non-sorted mBMSCs,...

After culturing these cells in vitro, they express the cell-surface molecules CD44, CD90, SH2 and SH3, and are negative for CD34 and the hematopoietic marker CD45. The aim of this study was to characterize the in vivo phenotype of MSC relative to the expression of CD34 and CD45.

Bone marrow stromal cells became quiescent, organized themselves forming a meshwork, deposited extracellular matrix, and formed specialized microenvironments that were recognized by hematopoietic CD34 + cells. Perivascular BMSC are α-SMA + quiescent cells with cytoplasmic projections that form a 3D meshwork and closely envelop hematopoietic ...