
Cell-type diversity in the bed nucleus of the stria terminalis to ...
2021年8月6日 · Over the past few decades, the bed nucleus of the stria terminalis (BNST) gained popularity as a unique brain region involved in regulating motivated behaviors related to neuropsychiatric disorders. The BNST, a component of the extended amygdala, consists of a variety of subnuclei and neuronal ensembles.
Corticotropin-releasing factor neurons in the bed nucleus of …
2021年6月14日 · Pharmacological studies have found that inhibiting corticotropin-releasing factor (CRF) signaling in the BNST can selectively mitigate the sensory and affective-motivational components of pain....
Parallel circuits from the bed nuclei of stria terminalis to the ...
2018年7月23日 · We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To...
Neurobiol Dis︱李晨/李伟研究团队揭示IC→PVT→BNST神经环路调 …
首先,作者在CaMKIIα-Cre小鼠PVT脑区注射AAV2/9-hSyn-DIO-hChR2-mCherry-WPRE-pA病毒,发现PVT具有向伏隔核(nucleus accumbens,NAc)、终纹床核(bed nucleus of the stria terminalis,BNST)和中杏仁核中央核(central nucleus of the amygdala,CeA)强大的正向神经纤维投射(图2A)。在WT小鼠BNST ...
Nature:破旧立新!终纹床核雌、雄调谐神经元单细胞水平调控攻 …
2022年8月7日 · 终纹床核( BNSTpr )是Esr1 调节性别差异行为的关键脑区。 另一方面, 可将雄激素转化为雌激素的芳香化酶仅存在于小鼠BNSTpr神经元亚群,表达芳香化酶的神经元群可编码辨别雌雄性别的信息,从而调控交配行为。 BNSTpr作为一个关键的中继站,从内侧杏仁核接收编码性别特异性嗅觉线索的输入,随后投射到下丘脑核团,分别控制交配(内侧视前区(MPOA))和攻击性行为(腹内侧下丘脑腹外侧核(VMHvl))。 2022年8月3日加州理工 …
Chemogenetic activation of corticotropin-releasing factor …
2023年7月14日 · Bed nucleus of the stria terminalis (BNST) is a limbic region associated with chronic stress and avoidance behaviors. Exposure to unpredictable fearful...
Bed Nucleus of the Stria Terminalis (BNST) neurons containing the ...
2023年9月26日 · Here, we investigated the effects of site-specific manipulation of the 5HT 2c receptor system in the BNST on operant alcohol self-administration behaviors in adult mice of both sexes, including the acquisition and maintenance of fixed-ratio responding, motivation for alcohol (progressive ratio), and quinine-adulterated responding for alcohol on ...
BNSTprEsr1 neurons represent intruder sex via a cell-identity code …
Calcium imaging in the medioventral bed nucleus of the stria terminalis (BNST) showed that social threats increased neural activity and that prepubertal castration generalized these responses to...
【文献解读】Nature Communications丨BNST相关微通路参与炎症 …
2023年4月27日 · 本研究以野生型和PKC-δ-Cre的C57BL/6小鼠为研究对象,使用光遗传学和化学遗传学等多种实验技术, 发现椭圆部BNST(ovBNST)内的PKC-δ+神经元参与动物炎症引起的厌食症状,并对正常动物的摄食行为发挥双向调控作用。 ovBNST内的PKC-δ+神经元接受ARC、LPB和CEA等多个摄食相关脑区的传入调控,并对腹外侧BNST(vlBNST)内对摄食活动有重要作用的LH投射神经元的活动发挥抑制性调节作用。 结果显示,BNST内的PKC-δ+神经元群及相 …
Mechanisms in the Bed Nucleus of the Stria Terminalis Involved in ...
The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay ...