2021年8月6日 · Over the past few decades, the bed nucleus of the stria terminalis (BNST) gained popularity as a unique brain region involved in regulating motivated behaviors related to neuropsychiatric disorders. The BNST, a component of the extended amygdala, consists of a variety of subnuclei and neuronal ensembles.

2021年6月14日 · Pharmacological studies have found that inhibiting corticotropin-releasing factor (CRF) signaling in the BNST can selectively mitigate the sensory and affective-motivational components of pain....

2018年7月23日 · We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To...

首先，作者在CaMKIIα-Cre小鼠PVT脑区注射AAV2/9-hSyn-DIO-hChR2-mCherry-WPRE-pA病毒，发现PVT具有向伏隔核（nucleus accumbens，NAc）、终纹床核（bed nucleus of the stria terminalis，BNST）和中杏仁核中央核（central nucleus of the amygdala，CeA）强大的正向神经纤维投射（图2A）。在WT小鼠BNST ...

2022年8月7日 · 终纹床核（ BNSTpr ）是Esr1 调节性别差异行为的关键脑区。 另一方面， 可将雄激素转化为雌激素的芳香化酶仅存在于小鼠BNSTpr神经元亚群，表达芳香化酶的神经元群可编码辨别雌雄性别的信息，从而调控交配行为。 BNSTpr作为一个关键的中继站，从内侧杏仁核接收编码性别特异性嗅觉线索的输入，随后投射到下丘脑核团，分别控制交配（内侧视前区（MPOA））和攻击性行为（腹内侧下丘脑腹外侧核（VMHvl））。 2022年8月3日加州理工 …

2023年7月14日 · Bed nucleus of the stria terminalis (BNST) is a limbic region associated with chronic stress and avoidance behaviors. Exposure to unpredictable fearful...

2023年9月26日 · Here, we investigated the effects of site-specific manipulation of the 5HT 2c receptor system in the BNST on operant alcohol self-administration behaviors in adult mice of both sexes, including the acquisition and maintenance of fixed-ratio responding, motivation for alcohol (progressive ratio), and quinine-adulterated responding for alcohol on ...

Calcium imaging in the medioventral bed nucleus of the stria terminalis (BNST) showed that social threats increased neural activity and that prepubertal castration generalized these responses to...

2023年4月27日 · 本研究以野生型和PKC-δ-Cre的C57BL/6小鼠为研究对象，使用光遗传学和化学遗传学等多种实验技术， 发现椭圆部BNST（ovBNST）内的PKC-δ+神经元参与动物炎症引起的厌食症状，并对正常动物的摄食行为发挥双向调控作用。 ovBNST内的PKC-δ+神经元接受ARC、LPB和CEA等多个摄食相关脑区的传入调控，并对腹外侧BNST（vlBNST）内对摄食活动有重要作用的LH投射神经元的活动发挥抑制性调节作用。 结果显示，BNST内的PKC-δ+神经元群及相 …

The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay ...