BQ.1和BQ.1.1由BA.5进化而来，而XBB和XBB.1是由两个BA.2谱系BJ.1和BA.2.75重组而来。 这两个亚系不断进化和多样化，使得刺突突变的复杂性不断增加。 （图片来自Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants） 主要BQ.1亚变体的 刺突蛋白 除了BA.5中发现的突变外，还含有K444T和N460K突变，BQ.1.1还有一个额外的R346T突变。 除了BA.2中发现的突变外，主要XBB亚变体的刺突有14个突变，包括5个在N端结构域 (NTD)的 …

Nov 17, 2022 · Omicron subvariants BQ.1 and BQ.1.1 now make up the majority of new COVID-19 cases in the United States, according to data from the Centers for Disease Control and Prevention (CDC). BQ.1 is now responsible for a fifth of U.S. COVID-19 cases while BQ.1.1 makes up a quarter of cases.

According to a statement by Pfizer in a press release, adults aged 55 and older were found to have nine times the normal number of antibodies against BQ.1.1 one month after receiving the bivalent booster. People who received a second dose of the first vaccination exhibited a significant rise in the number of antibodies they had against BQ1.16.

Nov 7, 2022 · We examined the degree of neutralising antibody escape by omicron subvariants BQ.1, BQ.1.1, BF.7, BA.1, BA.2, BA.2.75, and BA.4 and BA.5 (hereafter referred to as BA.4/5), using 50% neutralisation titres of six serum panels from individuals who had previously had delta BA.1 and BA.2.2 breakthrough infections and more recently had BA.5.1.2, BA.2....

目前，BQ.1和BQ.1.1也已成为美国的主要变异株（BQ.1+BQ.1.1已上升到了49.7%，BA.5%下降到了24%），超过新增病例的一半，从上图可以看出，BQ.1.1比BQ.1更值得我们警惕，接下来几周需要密切关注。 整体上看，BQ.1.1引起的住院率、ICU率有所增加，但死亡率仍在下降。 纽约是全美BQ.1.1流行率最高的州，从纽约的数据看，并没有引起住院率的增加，甚至有所下降。 尽管目前流行的还有其他变异株，最终也有可能占比超过BQ.1.1的变异株出现，但是根据德国癌症研究 …

Dec 13, 2022 · BA.5 is characterized by relatively mild cold and flu-like symptoms, with many people complaining about sore throats. BQ.1.1 and BQ.1 do not have radically different symptoms from previous...

Oct 28, 2022 · 病毒进化技术咨询小组表示，BQ.1*可能比其他流行的奥密克戎亚谱系具有免疫逃逸优势，可能有更高的再感染风险。 目前，没有流行病学数据表明疾病严重程度有所增加。 从 BQ.1* 观察到的免疫学变化对疫苗逃逸的影响仍有待确定。 根据现有的知识，疫苗对感染的保护作用可能会减弱，但预计不会对严重疾病的保护产生重大影响。...

Jun 27, 2023 · For people who had received three-dose inactivated vaccines prior to BF.7 breakthrough infection, they all had relatively high neutralization activities against BA.5 and its derivative variants,...

Jun 27, 2023 · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have seriously attacked the antibody barrier established by natural infection and/or vaccination, especially the recently emerged BQ.1.1 and XBB.1. However, crucial mechanisms underlying the virus escape and the broad neutralization remain elusive.

BQ.1是奥密克戎BA.5在人群流行传播过程中，通过病毒的变异变迁产生的第六代亚分支。 这些进化分支致病力明显减弱，致重症和死亡比例明显低于早期流行的变异毒株。 日本东京大学一项新研究显示，新冠病毒奥密克戎变异株BQ.1.1在40摄氏度的温度下增殖能力大幅减弱。