Response of the cerebral vasculature following traumatic brain injury
In this review, we delineate the vascular effects of TBI, its temporal response to injury and putative biomarkers for arterial and venous repair in TBI. We highlight several molecular pathways that may play a significant role in vascular repair after brain injury.
Cerebral blood vessel damage in traumatic brain injury
Apr 1, 2019 · Traumatic brain injury (TBI) is a devastating cause of death and disability, affecting approximately 1.7 million victims each year in the United States, approximately 50,000 of whom die (Faul et al., 2010); at the same time, global incidence of TBI is increasing dramatically (Maas et al., 2008). Patients who survive the initial trauma are ...
The neuropathology of traumatic brain injury - PMC
Traumatic brain injury (TBI) occurs when a force transmitted to the head or body results in neuropathologic damage and dysfunction. The US Department of Veterans Affairs and the Department of Defense's Clinical Practice Guideline For Management of Concussion/mTBI (version 1.0, April 2009) defines TBI as.
Blood–Brain Barrier Pathophysiology following Traumatic Brain Injury ...
Traumatic brain injury causes primary damage to the brain parenchyma, damaging cerebral microvessels and leads to NVU pathophysiology. The secondary damage from TBI begins with and revolves around the cerebral vasculature. From animal TBI models, we know that trauma disrupts the structural and physiological integrity of vessels.
Cellular and molecular mechanisms in vascular repair after …
Sep 4, 2023 · Blood vessels are often injured in TBI. Even in mild TBI, dysfunctional cerebral vascular repair may result in prolonged symptoms and poor outcomes. Various distinct types of cells participate in vascular repair after TBI.
Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury ...
Recent studies have shed light on the mechanisms of BBB breakdown in TBI including novel intracellular signaling and cell–cell interactions within the BBB niche. The current review provides an overview of the BBB, novel detection methods for disruption, and the cellular and molecular mechanisms implicated in regulating its stability following TBI.
Meningeal lymphatic dysfunction exacerbates traumatic brain injury ...
Sep 10, 2020 · Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma...
Cerebral blood vessel damage in traumatic brain injury
Traumatic brain injury is a devastating cause of death and disability. Although injury of brain tissue is of primary interest in head trauma, nearly all significant cases include damage of the cerebral blood vessels. Because vessels are critical to the maintenance of the healthy brain, any injury or …
Traumatic Brain Injury: A Comprehensive Review of …
May 1, 2024 · Traumatic brain injury (TBI) is a critical public health concern with profound consequences for affected individuals. This comprehensive literature review delves into TBI intricacies, encompassing primary injury biomechanics and the molecular pathophysiology of the secondary injury cascade.
Traumatic brain injury results in acute rarefication of the vascular ...
Mar 22, 2017 · We explored how cortical vessels are physically altered following TBI using a newly developed technique, vessel painting. We tested our hypothesis that a focal moderate TBI results in...