2023年5月8日 · 该研究利用 表观多组学 （ChIP-seq + ATAC-seq + RNA-seq）和机理表型实验 探究了BRD9（bromodomain-containing protein 9）在破骨细胞形成机制中的作用。 骨的功能和稳态依赖于平衡的骨重塑过程，这是一个由成骨细胞介导的骨形成和破骨细胞介导的骨吸收的连续循环过程。 骨重塑过程是经过精心策划的，它们的失衡会扰乱骨骼结构，引起骨质疏松、骨石化、骨坏死、Paget’s病等骨骼疾病。 破骨细胞是造血髓系，来源于骨髓源性单核细胞 (BMDMs)。

Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. [1] BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes. [2] The BRD9 gene is frequently present in variable copy number in lung cancer. [3]

2024年12月24日 · BRD9 (Bromodomain Containing 9) is a Protein Coding gene. Diseases associated with BRD9 include Sarcoma and Rhabdoid Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and lysine-acetylated histone binding. An important paralog of this gene is BRD7.

2019年4月23日 · We report that BRD9 (Bromodomain-containing protein 9) is a preferential dependency for SMARCB1 -mutant RT cells lines. Both shRNA-mediated BRD9 knockdown and CRISPR-Cas9-mediated BRD9...

2023年3月14日 · Bromodomain-containing protein 9 (BRD9), a component of non-canonical BAF chromatin remodeling complex, has been identified as a critical therapeutic...

最近的数据表明，BRD9 在调节细胞生长方面发挥着重要作用，并被认为可以推动宫颈癌、急性髓性白血病等多种恶性疾病的进展。 它在肿瘤发生中的作用表明选择性 BRD9 抑制剂可能在癌症治疗中具有治疗价值。 目前，人们越来越关注开发可以特异性靶向 BRD9 或密切相关的溴结构域蛋白 BRD7 的小分子。 可用的化学探针将有助于阐明 BRD9 的生物学功能及其治疗癌症的潜力。 自 2015 年第一个 BRD9 抑制剂 LP99 的报道以来，已经开发了许多抑制剂。 在这篇综述中，我们 …

2023年12月15日 · Motivated by recent discovery of disrupted expression of BRD9, an essential component of ncBAF, in multiple cancers, including clonal hematopoietic disorders, we evaluate here the role of BRD9...

2020年12月24日 · Bromodomain-containing protein 9 (BRD9) is a newly identified subunit of the non-canonical barrier-to-autointegration factor (ncBAF) complex and a member of the bromodomain family IV. Studies have confirmed that BRD9 plays an oncogenic role in multiple cancer types, by regulating tumor cell growth.

2023年3月14日 · Bromodomain-containing protein 9 (BRD9), a component of non-canonical BAF chromatin remodeling complex, has been identified as a critical therapeutic target in hematological diseases. Despite the hematopoietic origin of osteoclasts, the role of BRD9 in osteoclastogenesis and bone diseases remains un …

2022年12月13日 · We find that BRD9 is dispensable for human induced pluripotent stem cells under primed but not under naive conditions. Mechanistically, BRD9 inhibition downregulates fibroblast-related genes and decreases chromatin accessibility at somatic enhancers.